2022
Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs
Wiley K, Camilo C, Gouveia G, Euclydes V, Panter‐Brick C, Matijasevich A, Ferraro A, Fracolli L, Chiesa A, Miguel E, Polanczyk G, Brentani H. Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs. Developmental Psychobiology 2022, 65: e22352. PMID: 36567654, PMCID: PMC9792831, DOI: 10.1002/dev.22352.Peer-Reviewed Original ResearchConceptsPrenatal psychological distressLate pregnancyMaternal prenatal psychosocial stressMaternal hair cortisolMaternal prenatal psychological distressPrenatal psychosocial stressPsychological distressAdrenal axis functionInfants of mothersEvening salivary cortisolMother-infant pairsInfant DNA methylationMultivariable linear regressionHair cortisol concentrationsElevated anxiety symptomsAxis functionFetal programingEvening cortisolPregnant adolescentsMaternal distressPsychosocial stressCortisol concentrationsPregnancyHair cortisolSalivary cortisolNovel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth
Mulligan CJ, Clukay CJ, Matarazzo A, Hadfield K, Nevell L, Dajani R, Panter-Brick C. Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth. PLOS ONE 2022, 17: e0266509. PMID: 35377919, PMCID: PMC8979449, DOI: 10.1371/journal.pone.0266509.Peer-Reviewed Original ResearchConceptsProtective effectTrauma exposureHealth-focused interventionsGenetic variantsDirect protective effectAltered stress reactivityLifetime trauma exposureEarly life adversityPost-traumatic stress symptomsHigh expression variantsOutcome measuresControl studyPsychosocial stressGene x environment interactionsHealth trajectoriesLife adversityMental healthTime pointsWar-related traumaStress reactivityTraumaHigh levelsLongitudinal studyEffects of geneticsPsychosocial environment
2019
Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees
Clukay CJ, Dajani R, Hadfield K, Quinlan J, Panter-Brick C, Mulligan CJ. Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees. PLOS ONE 2019, 14: e0219385. PMID: 31314763, PMCID: PMC6636744, DOI: 10.1371/journal.pone.0219385.Peer-Reviewed Original ResearchConceptsPsychosocial stressPerceived Stress ScaleTrauma exposureProtective factorsGenetic variantsLow trauma exposureHigh trauma exposureMental health measuresMental health trajectoriesAdult mental healthSymptom scoresPsychosocial healthPsychosocial factorsEarly childhood traumaHealth measuresHealth trajectoriesMental healthTraumaMonoamine oxidaseTime pointsPsychosocial wellbeingLifelong effectsChildhood traumaHigher resilience levelsLongitudinal study
2008
Social stressors, mental health, and physiological stress in an urban elite of young Afghans in Kabul
Panter‐Brick C, Eggerman M, Mojadidi A, McDade TW. Social stressors, mental health, and physiological stress in an urban elite of young Afghans in Kabul. American Journal Of Human Biology 2008, 20: 627-641. PMID: 18663740, DOI: 10.1002/ajhb.20797.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdultAfghanistanBrief Psychiatric Rating ScaleCross-Sectional StudiesEpstein-Barr Virus InfectionsFamily ConflictFemaleHealth Status IndicatorsHumansHypertensionMalePrevalenceSeroepidemiologic StudiesSex DistributionSocial ClassSocial EnvironmentStress, PhysiologicalStress, PsychologicalUrban PopulationYoung AdultConceptsPsychosocial distressElevated EBV antibody titersMental healthEBV antibody titersDiastolic blood pressureMental health assessmentPoor mental healthMental health problemsSocial stressorsBlood pressureAntibody titersHealth problemsPsychosocial stressPhysical healthHealth assessmentPhysiological wellbeingRandom sampleDistressPhysiological markersDay stressorsWomenHealthFamily stressorsPhysiological functionsUrban elitesHomeless street children in Nepal: Use of allostatic load to assess the burden of childhood adversity
Worthman CM, Panter-Brick C. Homeless street children in Nepal: Use of allostatic load to assess the burden of childhood adversity. Development And Psychopathology 2008, 20: 233-255. PMID: 18211736, DOI: 10.1017/s0954579408000114.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAllostasisAlpha 1-AntichymotrypsinAntibodies, ViralArousalBody HeightBody WeightChildDeveloping CountriesHeart RateHerpesvirus 4, HumanHomeless YouthHumansHydrocortisoneLife StyleMaleNepalPhysical FitnessPovertyPsychosocial DeprivationRisk FactorsRural PopulationSalivaUrban PopulationConceptsAllostatic loadChildhood adversityAcute phase inflammatory responseEpstein-Barr virusDevelopmental riskRisk factorsInflammatory responseCommon conditionCardiovascular fitnessBiomarkers of stressCumulative burdenPsychosocial stressNepali childrenIndividual biomarkersSalivary cortisolUrban squatter settlementsHomeless street childrenUrban middle classChildrenRiskBiomarkersCritical appraisalNon-Western settingsFamily-based groupsBurden