Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs
Wiley K, Camilo C, Gouveia G, Euclydes V, Panter‐Brick C, Matijasevich A, Ferraro A, Fracolli L, Chiesa A, Miguel E, Polanczyk G, Brentani H. Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs. Developmental Psychobiology 2022, 65: e22352. PMID: 36567654, PMCID: PMC9792831, DOI: 10.1002/dev.22352.Peer-Reviewed Original ResearchConceptsPrenatal psychological distressLate pregnancyMaternal prenatal psychosocial stressMaternal hair cortisolMaternal prenatal psychological distressPrenatal psychosocial stressPsychological distressAdrenal axis functionInfants of mothersEvening salivary cortisolMother-infant pairsInfant DNA methylationMultivariable linear regressionHair cortisol concentrationsElevated anxiety symptomsAxis functionFetal programingEvening cortisolPregnant adolescentsMaternal distressPsychosocial stressCortisol concentrationsPregnancyHair cortisolSalivary cortisol