Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth
Mulligan CJ, Clukay CJ, Matarazzo A, Hadfield K, Nevell L, Dajani R, Panter-Brick C. Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth. PLOS ONE 2022, 17: e0266509. PMID: 35377919, PMCID: PMC8979449, DOI: 10.1371/journal.pone.0266509.Peer-Reviewed Original ResearchConceptsProtective effectTrauma exposureHealth-focused interventionsGenetic variantsDirect protective effectAltered stress reactivityLifetime trauma exposureEarly life adversityPost-traumatic stress symptomsHigh expression variantsOutcome measuresControl studyPsychosocial stressGene x environment interactionsHealth trajectoriesLife adversityMental healthTime pointsWar-related traumaStress reactivityTraumaHigh levelsLongitudinal studyEffects of geneticsPsychosocial environment