2020
Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology–histopathology correlation in 7 patients
Darbinyan A, Morotti R, Cai G, Prasad ML, Christison‐Lagay E, Dinauer C, Adeniran AJ. Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology–histopathology correlation in 7 patients. Cancer Cytopathology 2020, 128: 746-756. PMID: 32897650, DOI: 10.1002/cncy.22329.Peer-Reviewed Original ResearchConceptsDICER1 mutationsThyroid diseaseThyroid carcinomaScreening of patientsFine-needle aspiration samplesMonitoring of patientsDiagnostic cytologic featuresPapillary thyroid carcinomaGermline DICER1 mutationsThyroid fine-needle aspiration samplesFNA evaluationUndetermined significanceDifferent somatic variantsThyroid cancerScant colloidNeoplastic lesionsHistopathological analysisCytomorphologic featuresDICER1 syndromeModerate cellularityCytologic featuresFollicular carcinomaFollicular lesionsInconspicuous nucleoliFollicular neoplasmPediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee
Christison-Lagay ER, Baertschiger RM, Dinauer C, Francis G, Malek M, Lautz T, Aldrink J, Grant C, Rhee D, Ehrlich P, Dasgupta R, Abdessalam S, Committee O. Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee. Journal Of Pediatric Surgery 2020, 55: 2273-2283. PMID: 32553450, DOI: 10.1016/j.jpedsurg.2020.05.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsThyroid cancerPediatric DTCAPSA Cancer CommitteeSurgical therapeutic approachUnresectable progressive diseaseLymph node basinCornerstone of treatmentAutoimmune thyroid diseaseLong-term recurrenceFine-needle aspirationNode basinTotal thyroidectomyProgressive diseaseSurgical resectionRadiological featuresSurvival outcomesCancer CommitteeThyroid diseaseTreatment strategiesFamily historyTreatment decisionsNeedle aspirationTherapeutic approachesThyroid carcinomaIodine deficiencyRecurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice
Rubinstein JC, Herrick-Reynolds K, Dinauer C, Morotti R, Solomon D, Callender GG, Christison-Lagay ER. Recurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice. Journal Of Surgical Research 2020, 249: 58-66. PMID: 31923715, DOI: 10.1016/j.jss.2019.12.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsChildFemaleFollow-Up StudiesHospitals, High-VolumeHumansLymph NodesLymphatic MetastasisMaleNeoplasm Recurrence, LocalPostoperative ComplicationsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsSurvival AnalysisThyroid Cancer, PapillaryThyroid GlandThyroid NeoplasmsThyroidectomyTreatment OutcomeYoung AdultConceptsPediatric papillary thyroid cancerLateral neck diseaseNeck diseasePapillary thyroid cancerNode involvementThyroid cancerExact testLymph node involvementCentral neck dissectionExtent of diseasePredictors of recurrenceRetrospective case seriesNon-Caucasian raceCox proportional hazardsLateral node involvementHigh-volume practiceFisher's exact testDisease recurrenceLymphovascular invasionMedian ageNeck dissectionCase seriesIndependent predictorsRetrospective reviewTumor size
2018
Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer
Rubinstein JC, Dinauer C, Herrick-Reynolds K, Morotti R, Callender GG, Christison-Lagay ER. Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer. Journal Of Pediatric Surgery 2018, 54: 129-132. PMID: 30361076, DOI: 10.1016/j.jpedsurg.2018.10.010.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerPediatric patientsTotal thyroidectomyNeck dissectionThyroid cancerN1b papillary thyroid cancerPediatric papillary thyroid cancerProphylactic central neck dissectionRegional lymph node metastasisCentral neck dissectionRetrospective case seriesLymph node metastasisRadical neck dissectionTime of presentationLikelihood of recurrenceTime of operationMedian ageMedian durationMetastatic LNsNode metastasisCase seriesPediatric populationPrognostic predictorSingle institutionSingle recurrence
2017
Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma
Hardee S, Prasad ML, Hui P, Dinauer CA, Morotti RA. Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma. Pediatric And Developmental Pathology 2017, 20: 206-212. PMID: 28521635, DOI: 10.1177/1093526616689628.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerPediatric papillary thyroid cancerPrognostic implicationsPediatric papillary thyroid carcinomaNegative casesBRAF-negative casesBRAF-negative patientsBRAF-positive casesTertiary medical centerAggressive clinical coursePapillary thyroid carcinomaSurgical pathology diagnosisCommon genetic aberrationsNegative patientsAggressive courseClinical coursePathologic characteristicsCase seriesClinical outcomesRetrospective reviewAggressive featuresPediatric casesRecurrence rateRetrospective studySingle institution
2016
NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States
Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, Tallini G, Nikiforova MN, Christison-Lagay ER, Udelsman R, Dinauer CA, Nikiforov YE. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Cancer 2016, 122: 1097-1107. PMID: 26784937, DOI: 10.1002/cncr.29887.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCarcinomaCarcinoma, PapillaryChildDNA Mutational AnalysisFemaleHigh-Throughput Nucleotide SequencingHumansMaleMutationNew EnglandNuclear Pore Complex ProteinsOncogene Proteins, FusionProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-etsProto-Oncogene Proteins c-retReceptor, trkAReceptor, trkCRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionThyroid Cancer, PapillaryThyroid Neoplasms
2015
C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain
Abi-Raad R, Virk RK, Dinauer CA, Prasad A, Morotti RA, Breuer CK, Sosa JA, Udelsman R, Rivkees SA, Prasad ML. C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain. Human Pathology 2015, 46: 1121-1128. PMID: 26033033, DOI: 10.1016/j.humpath.2015.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarcinoma, NeuroendocrineChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGerm-Line MutationHeterozygoteHumansInfantMaleMiddle AgedMultiple Endocrine NeoplasiaProtein Structure, TertiaryProto-Oncogene MasProto-Oncogene Proteins c-retThyroid NeoplasmsYoung AdultConceptsMedullary thyroid carcinomaMultiple endocrine neoplasia type 2C-cell hyperplasiaAsymptomatic carriersC-cell neoplasiaRET mutationsMTC familiesHigh-risk RET mutationsIntracellular tyrosine kinase domainTyrosine kinase domainC-cell diseaseC-cell pathologyLymph node metastasisCodon 918 mutationYounger median ageReceptor tyrosine kinase proteinTotal thyroidectomyProgressive diseaseMedian ageNode metastasisThyroid carcinomaType 2Germline mutationsTyrosine kinase proteinFormer group
2004
The MACIS Score Predicts the Clinical Course of Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Francis GL. The MACIS Score Predicts the Clinical Course of Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2004, 17: 339-344. PMID: 15112910, DOI: 10.1515/jpem.2004.17.3.339.Peer-Reviewed Original Research
2003
Treatment of Recurrent Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Francis GL. Treatment of Recurrent Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2003, 16: 1033-1040. PMID: 14513881, DOI: 10.1515/jpem.2003.16.7.1033.Peer-Reviewed Original ResearchConceptsRecurrent papillary thyroid carcinomaPapillary thyroid carcinomaThyroid carcinomaYears of ageThird remissionCervical nodesPersistent diseaseClinical coursePoor prognosisSecond recurrenceHigh mortalityRemissionChildrenCarcinomaRecurrenceMortalityTreatmentAdultsPrevious dataPatientsPrognosisDiseaseTumor Size and Extent of Disease at Diagnosis Predict the Response to Initial Therapy for Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Robie DK, McClellan DR, Francis GL. Tumor Size and Extent of Disease at Diagnosis Predict the Response to Initial Therapy for Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2003, 16: 693-702. PMID: 12880118, DOI: 10.1515/jpem.2003.16.5.693.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaExtent of diseaseLarger tumor sizeTumor sizeExtensive diseaseInitial treatmentThyroid carcinomaRadioactive iodine treatmentClass IV patientsInitial therapyFirst remissionIV patientsPersistent diseaseMultifocal diseasePatientsClass IIIRemissionClass IIIodine treatmentDiseaseClass IDiagnosisTreatmentCarcinomaChildren
2002
Intense Expression of the B7-2 Antigen Presentation Coactivator Is an Unfavorable Prognostic Indicator for Differentiated Thyroid Carcinoma of Children and Adolescents
Shah R, Banks K, Patel A, Dogra S, Terrell R, Powers PA, Fenton C, Dinauer CA, Tuttle RM, Francis GL. Intense Expression of the B7-2 Antigen Presentation Coactivator Is an Unfavorable Prognostic Indicator for Differentiated Thyroid Carcinoma of Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 4391-4397. PMID: 12213904, DOI: 10.1210/jc.2002-011262.Peer-Reviewed Original ResearchConceptsB7-2 expressionThyroid carcinomaLymphocytic infiltrationB7-1B7-2Immune responseAdjacent thyroidImproved disease-free survivalDisease-free survivalTumor-associated lymphocytesDifferentiated thyroid carcinomaProbability of remissionUnfavorable prognostic indicatorB7-1 expressionFollicular thyroid carcinomaLong-term survivalHigh-power fieldBenign thyroid lesionsPrognostic indicatorThyroid diseaseAntigen presentationBenign tumorsMalignant tumorsCarcinomaThyroid lesions
2001
Infiltration of Differentiated Thyroid Carcinoma by Proliferating Lymphocytes Is Associated with Improved Disease-Free Survival for Children and Young Adults1
Gupta S, Patel A, Folstad A, Fenton C, Dinauer C, Tuttle R, Conran R, Francis G. Infiltration of Differentiated Thyroid Carcinoma by Proliferating Lymphocytes Is Associated with Improved Disease-Free Survival for Children and Young Adults1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1346-1354. PMID: 11238531, DOI: 10.1210/jcem.86.3.7310.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, FollicularAdolescentAdultCarcinoma, MedullaryCarcinoma, PapillaryCell DivisionChildDisease-Free SurvivalFemaleHumansImmunohistochemistryKi-67 AntigenLeukocyte Common AntigensLymphatic MetastasisLymphocytesMaleNeoplasm MetastasisNeoplasm Recurrence, LocalThyroid NeoplasmsConceptsDisease-free survivalPapillary thyroid carcinomaImproved disease-free survivalTumor-associated lymphocytesNumber of lymphocytesThyroid cancerThyroid carcinomaFollicular thyroid carcinomaHigh-power fieldYoung adultsAutoimmune thyroiditisImmune responseKi-67 positive lymphocytesRegional lymph node involvementMultifocal papillary thyroid carcinomaChildhood papillary thyroid carcinomasLymph node involvementDifferentiated thyroid cancerDifferentiated thyroid carcinomaLong-term outcomesPower fieldPresence of lymphocytesMedullary thyroid carcinomaHigh proliferation indexMajority of PTC
2000
Over‐expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma
Ramirez R, Hsu D, Patel A, Fenton C, Dinauer C, Tuttle R, Francis G. Over‐expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma. Clinical Endocrinology 2000, 53: 635-644. PMID: 11106926, DOI: 10.1046/j.1365-2265.2000.01124.x.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaFollicular thyroid carcinomaDisease-free survivalHGF/SF expressionMedullary thyroid carcinomaThyroid carcinomaHepatocyte growth factor/scatter factorGrowth factor/scatter factorYoung adultsFree survivalHigh riskHGF/SF receptorHGF/SFShorter disease-free survivalNormal thyroidExtent of diseaseSF expressionBenign thyroid disordersExpression of cMetIntensity of expressionMalignant thyroid lesionsClinical outcomesRetrospective groupThyroid disordersThyroid cancerThe Expression of Vascular Endothelial Growth Factor and the Type 1 Vascular Endothelial Growth Factor Receptor Correlate with the Size of Papillary Thyroid Carcinoma in Children and Young Adults
Fenton C, Patel A, Dinauer C, Robie D, Tuttle R, Francis G. The Expression of Vascular Endothelial Growth Factor and the Type 1 Vascular Endothelial Growth Factor Receptor Correlate with the Size of Papillary Thyroid Carcinoma in Children and Young Adults. Thyroid 2000, 10: 349-357. PMID: 10807064, DOI: 10.1089/thy.2000.10.349.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, FollicularAdolescentAdultCarcinoma, PapillaryCase-Control StudiesChildEndothelial Growth FactorsFemaleHumansLymphokinesMaleProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, Growth FactorThyroid NeoplasmsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsVascular endothelial growth factorExpression of VEGFPapillary thyroid carcinomaEndothelial growth factorThyroid carcinomaBenign lesionsYoung adultsClinical outcomesThyroid cancerPTC sizeVEGF expressionFlt-1Growth factorRetrospective clinical outcomesChildhood thyroid cancerThyroid tissue blocksFollicular thyroid carcinomaFlt-1 expressionRecurrent diseaseSolid tumorsCarcinomaVEGF receptorsReceptor correlatesLesionsTissue blocksTyrosine kinase expression is increased in papillary thyroid carcinoma of children and young adults.
Patel A, Fenton C, Ramirez R, Dinauer CA, Tuttle RM, Nikiforov YE, Gary FL. Tyrosine kinase expression is increased in papillary thyroid carcinoma of children and young adults. Frontiers In Bioscience-Landmark 2000, 5: a1-9. PMID: 10702379, DOI: 10.2741/patel.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarcinoma, PapillaryChildEndothelial Growth FactorsFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryLymphokinesMalePhosphorylationProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-metReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorRegistriesThyroid NeoplasmsTyrosineVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsThyroid carcinomaRecurrence riskYoung adultsTK expressionTyrosine kinaseThyroid tissue blocksPapillary thyroid carcinomaTyrosine kinase expressionHepatocyte growth factor/scatter factorGrowth factor/scatter factorYounger patientsClinical behaviorBenign lesionsThyroid glandMalignant transformationIndividual tumorsTissue blocksKinase expressionCarcinomaDifferent tyrosine kinasesAdultsScatter factorChildrenPTCRisk
1999
Extensive surgery improves recurrence-free survival for children and young patients with class I papillary thyroid carcinoma
Dinauer C, Tuttle R, Robie D, McClellan D, Francis G. Extensive surgery improves recurrence-free survival for children and young patients with class I papillary thyroid carcinoma. Journal Of Pediatric Surgery 1999, 34: 1799-1804. PMID: 10626858, DOI: 10.1016/s0022-3468(99)90316-0.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerRisk of complicationsExtensive surgeryRadioactive iodineHigh riskThyroid hormonesRecurrent papillary thyroid cancerIncidence of complicationsRecurrence-free survivalRisk of recurrenceYears of agePapillary thyroid carcinomaInitial surgeryPermanent hypoparathyroidismSubtotal thyroidectomyTotal thyroidectomyAdjunctive therapySurgical complicationsSurgical groupYounger patientsMultifocal diseaseMultifocal tumorsContralateral lobeOptimal treatmentThyroid cancerRas mutations are uncommon in sporadic thyroid cancer in children and young adults
Fenton C, Anderson J, Lukes Y, Dinauer C, Tuttle RM, Francis GL. Ras mutations are uncommon in sporadic thyroid cancer in children and young adults. Journal Of Endocrinological Investigation 1999, 22: 781-789. PMID: 10614528, DOI: 10.1007/bf03343644.Peer-Reviewed Original ResearchConceptsMedullary thyroid cancerFollicular thyroid cancerChildhood thyroid cancerThyroid cancerPrevious radiation exposureRas mutationsRadiation exposureCodon 12Aggressive papillary thyroid cancerAdult thyroid cancerClass II diseaseSporadic thyroid cancerPapillary thyroid cancerArchival tissue blocksLung metastasesCancer 4Number of subjectsPatientsCancerLymphomaYoung adultsTissue blocksHuman cancersChildrenPrevious reports
1998
Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults
Dinauer C, Tuttle M, Robie D, McClellan D, Svec R, Adair C, Francis G. Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults. Clinical Endocrinology 1998, 49: 619-628. PMID: 10197078, DOI: 10.1046/j.1365-2265.1998.00584.x.Peer-Reviewed Original ResearchConceptsDifferentiated thyroid cancerThyroid cancerClinical featuresMultifocal tumorsCases of FTCPalpable cervical lymphadenopathyRisk of recurrenceYears of ageCases of PTCCervical lymphadenopathyDistant recurrenceYounger patientsTumor RegistryFTC groupPathological findingsRetrospective studyLarge tumorsUnivariate analysisFollicular variantPTC groupHigh riskPatientsRecurrenceLower mortalityGreater risk