2021
Management of Pediatric Graves Disease
Quintanilla-Dieck L, Khalatbari HK, Dinauer CA, Rastatter JC, Chelius DC, Katowitz WR, Shindo ML, Parisi MT, Kazahaya K. Management of Pediatric Graves Disease. JAMA Otolaryngology - Head & Neck Surgery 2021, 147: 1110-1118. PMID: 34647991, DOI: 10.1001/jamaoto.2021.2715.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGraves' diseaseClinical presenting signsPediatric Graves' diseaseSustained remission rateRadioactive iodine therapyFirst-line treatmentSpecific clinical characteristicsMultidisciplinary approachIodine therapyRemission rateClinical characteristicsDefinitive treatmentMedical therapyPediatric patientsPresenting signMedical managementPediatric populationAntithyroid drugsTherapeutic optionsCertain patientsTreatment optionsOptimal treatmentThyroid ultrasonographyPediatric expertsNuclear medicine
2020
Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee
Christison-Lagay ER, Baertschiger RM, Dinauer C, Francis G, Malek M, Lautz T, Aldrink J, Grant C, Rhee D, Ehrlich P, Dasgupta R, Abdessalam S, Committee O. Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee. Journal Of Pediatric Surgery 2020, 55: 2273-2283. PMID: 32553450, DOI: 10.1016/j.jpedsurg.2020.05.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdolescentChildChild, PreschoolFemaleHumansNeoplasm Recurrence, LocalThyroid NeoplasmsThyroid NoduleThyroidectomyConceptsThyroid cancerPediatric DTCAPSA Cancer CommitteeSurgical therapeutic approachUnresectable progressive diseaseLymph node basinCornerstone of treatmentAutoimmune thyroid diseaseLong-term recurrenceFine-needle aspirationNode basinTotal thyroidectomyProgressive diseaseSurgical resectionRadiological featuresSurvival outcomesCancer CommitteeThyroid diseaseTreatment strategiesFamily historyTreatment decisionsNeedle aspirationTherapeutic approachesThyroid carcinomaIodine deficiency
2017
Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma
Hardee S, Prasad ML, Hui P, Dinauer CA, Morotti RA. Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma. Pediatric And Developmental Pathology 2017, 20: 206-212. PMID: 28521635, DOI: 10.1177/1093526616689628.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerPediatric papillary thyroid cancerPrognostic implicationsPediatric papillary thyroid carcinomaNegative casesBRAF-negative casesBRAF-negative patientsBRAF-positive casesTertiary medical centerAggressive clinical coursePapillary thyroid carcinomaSurgical pathology diagnosisCommon genetic aberrationsNegative patientsAggressive courseClinical coursePathologic characteristicsCase seriesClinical outcomesRetrospective reviewAggressive featuresPediatric casesRecurrence rateRetrospective studySingle institution
2015
C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain
Abi-Raad R, Virk RK, Dinauer CA, Prasad A, Morotti RA, Breuer CK, Sosa JA, Udelsman R, Rivkees SA, Prasad ML. C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain. Human Pathology 2015, 46: 1121-1128. PMID: 26033033, DOI: 10.1016/j.humpath.2015.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarcinoma, NeuroendocrineChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGerm-Line MutationHeterozygoteHumansInfantMaleMiddle AgedMultiple Endocrine NeoplasiaProtein Structure, TertiaryProto-Oncogene MasProto-Oncogene Proteins c-retThyroid NeoplasmsYoung AdultConceptsMedullary thyroid carcinomaMultiple endocrine neoplasia type 2C-cell hyperplasiaAsymptomatic carriersC-cell neoplasiaRET mutationsMTC familiesHigh-risk RET mutationsIntracellular tyrosine kinase domainTyrosine kinase domainC-cell diseaseC-cell pathologyLymph node metastasisCodon 918 mutationYounger median ageReceptor tyrosine kinase proteinTotal thyroidectomyProgressive diseaseMedian ageNode metastasisThyroid carcinomaType 2Germline mutationsTyrosine kinase proteinFormer group
2004
The MACIS Score Predicts the Clinical Course of Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Francis GL. The MACIS Score Predicts the Clinical Course of Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2004, 17: 339-344. PMID: 15112910, DOI: 10.1515/jpem.2004.17.3.339.Peer-Reviewed Original Research
2003
Tumor Size and Extent of Disease at Diagnosis Predict the Response to Initial Therapy for Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Robie DK, McClellan DR, Francis GL. Tumor Size and Extent of Disease at Diagnosis Predict the Response to Initial Therapy for Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2003, 16: 693-702. PMID: 12880118, DOI: 10.1515/jpem.2003.16.5.693.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaExtent of diseaseLarger tumor sizeTumor sizeExtensive diseaseInitial treatmentThyroid carcinomaRadioactive iodine treatmentClass IV patientsInitial therapyFirst remissionIV patientsPersistent diseaseMultifocal diseasePatientsClass IIIRemissionClass IIIodine treatmentDiseaseClass IDiagnosisTreatmentCarcinomaChildren