2002
Intense Expression of the B7-2 Antigen Presentation Coactivator Is an Unfavorable Prognostic Indicator for Differentiated Thyroid Carcinoma of Children and Adolescents
Shah R, Banks K, Patel A, Dogra S, Terrell R, Powers PA, Fenton C, Dinauer CA, Tuttle RM, Francis GL. Intense Expression of the B7-2 Antigen Presentation Coactivator Is an Unfavorable Prognostic Indicator for Differentiated Thyroid Carcinoma of Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 4391-4397. PMID: 12213904, DOI: 10.1210/jc.2002-011262.Peer-Reviewed Original ResearchConceptsB7-2 expressionThyroid carcinomaLymphocytic infiltrationB7-1B7-2Immune responseAdjacent thyroidImproved disease-free survivalDisease-free survivalTumor-associated lymphocytesDifferentiated thyroid carcinomaProbability of remissionUnfavorable prognostic indicatorB7-1 expressionFollicular thyroid carcinomaLong-term survivalHigh-power fieldBenign thyroid lesionsPrognostic indicatorThyroid diseaseAntigen presentationBenign tumorsMalignant tumorsCarcinomaThyroid lesionsNitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents
Patel A, Fenton C, Terrell R, Powers P, Dinauer C, Tuttle R, Francis G. Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 675-683. PMID: 12240898, DOI: 10.1007/bf03345100.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseEndothelial nitric oxide synthaseFollicular thyroid carcinomaPapillary thyroid carcinomaNitric oxide synthaseAutoimmune lesionsBenign adenomasMultinodular goiterNitric oxideThyroid tumorsNormal thyroidOxide synthaseThyroid carcinomaAutoimmune thyroid diseaseNeuronal NO synthaseVascular endothelial growth factorHigh-power fieldMatrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents
Patel A, Straight A, Mann H, Duffy E, Fenton C, Dinauer C, Tuttle R, Francis G. Matrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 403-408. PMID: 12035934, DOI: 10.1007/bf03344028.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaFollicular thyroid carcinomaThyroid carcinomaTIMP-1MMP-1MMP-1 expressionMatrix metalloproteinasesMT1-MMPRecurrent papillary thyroid carcinomaTumor-associated inflammatory cellsPrevious pathological studiesTumor-associated lymphocytesDifferentiated thyroid carcinomaTIMP-1 expressionMatrix metalloproteinase expressionThyroid cancer cellsIntensity of stainingBenign thyroid lesionsMembrane type-1 matrix metalloproteinasesInflammatory cellsPathological studiesNormal thyroid cellsMalignant lesionsBenign lesionsMetalloproteinase expressionThyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents
Straight A, Patel A, Fenton C, Dinauer C, Tuttle R, Francis G. Thyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 302-308. PMID: 12030599, DOI: 10.1007/bf03344009.Peer-Reviewed Original ResearchConceptsFollicular thyroid carcinomaPapillary thyroid carcinomaThyroid carcinomaMalignant tumorsTelomerase expressionDisease-free survivalAggressive clinical courseChildhood thyroid cancerHigh recurrence riskYr of ageBenign thyroid lesionsLow telomerase expressionAutoimmune lesionsClinical courseDistant metastasisDirect invasionThyroid cancerBenign tumorsBlind examinerOriginal tumorBenign lesionsRecurrence riskTumorsThyroid lesionsCarcinoma
2001
Infiltration of Differentiated Thyroid Carcinoma by Proliferating Lymphocytes Is Associated with Improved Disease-Free Survival for Children and Young Adults1
Gupta S, Patel A, Folstad A, Fenton C, Dinauer C, Tuttle R, Conran R, Francis G. Infiltration of Differentiated Thyroid Carcinoma by Proliferating Lymphocytes Is Associated with Improved Disease-Free Survival for Children and Young Adults1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1346-1354. PMID: 11238531, DOI: 10.1210/jcem.86.3.7310.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, FollicularAdolescentAdultCarcinoma, MedullaryCarcinoma, PapillaryCell DivisionChildDisease-Free SurvivalFemaleHumansImmunohistochemistryKi-67 AntigenLeukocyte Common AntigensLymphatic MetastasisLymphocytesMaleNeoplasm MetastasisNeoplasm Recurrence, LocalThyroid NeoplasmsConceptsDisease-free survivalPapillary thyroid carcinomaImproved disease-free survivalTumor-associated lymphocytesNumber of lymphocytesThyroid cancerThyroid carcinomaFollicular thyroid carcinomaHigh-power fieldYoung adultsAutoimmune thyroiditisImmune responseKi-67 positive lymphocytesRegional lymph node involvementMultifocal papillary thyroid carcinomaChildhood papillary thyroid carcinomasLymph node involvementDifferentiated thyroid cancerDifferentiated thyroid carcinomaLong-term outcomesPower fieldPresence of lymphocytesMedullary thyroid carcinomaHigh proliferation indexMajority of PTC
2000
Over‐expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma
Ramirez R, Hsu D, Patel A, Fenton C, Dinauer C, Tuttle R, Francis G. Over‐expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma. Clinical Endocrinology 2000, 53: 635-644. PMID: 11106926, DOI: 10.1046/j.1365-2265.2000.01124.x.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaFollicular thyroid carcinomaDisease-free survivalHGF/SF expressionMedullary thyroid carcinomaThyroid carcinomaHepatocyte growth factor/scatter factorGrowth factor/scatter factorYoung adultsFree survivalHigh riskHGF/SF receptorHGF/SFShorter disease-free survivalNormal thyroidExtent of diseaseSF expressionBenign thyroid disordersExpression of cMetIntensity of expressionMalignant thyroid lesionsClinical outcomesRetrospective groupThyroid disordersThyroid cancerThe Expression of Vascular Endothelial Growth Factor and the Type 1 Vascular Endothelial Growth Factor Receptor Correlate with the Size of Papillary Thyroid Carcinoma in Children and Young Adults
Fenton C, Patel A, Dinauer C, Robie D, Tuttle R, Francis G. The Expression of Vascular Endothelial Growth Factor and the Type 1 Vascular Endothelial Growth Factor Receptor Correlate with the Size of Papillary Thyroid Carcinoma in Children and Young Adults. Thyroid 2000, 10: 349-357. PMID: 10807064, DOI: 10.1089/thy.2000.10.349.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, FollicularAdolescentAdultCarcinoma, PapillaryCase-Control StudiesChildEndothelial Growth FactorsFemaleHumansLymphokinesMaleProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, Growth FactorThyroid NeoplasmsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsVascular endothelial growth factorExpression of VEGFPapillary thyroid carcinomaEndothelial growth factorThyroid carcinomaBenign lesionsYoung adultsClinical outcomesThyroid cancerPTC sizeVEGF expressionFlt-1Growth factorRetrospective clinical outcomesChildhood thyroid cancerThyroid tissue blocksFollicular thyroid carcinomaFlt-1 expressionRecurrent diseaseSolid tumorsCarcinomaVEGF receptorsReceptor correlatesLesionsTissue blocks