2008
Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise
Duman CH, Schlesinger L, Terwilliger R, Russell DS, Newton SS, Duman RS. Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise. Behavioural Brain Research 2008, 198: 366-371. PMID: 19056428, PMCID: PMC2729431, DOI: 10.1016/j.bbr.2008.11.016.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorAntidepressant-like behaviorForced-swim testGrowth factorChronic IGF-I treatmentNovelty-induced hypophagia testIGF-I administrationEffects of exerciseIGF-I treatmentAntidepressant effectsHypophagia testNeurotrophic factorNeurotrophic mechanismsStress exposureDepressionFunctional relevanceTreatmentFactorsMiceAdministrationBrainVoluntary exercise produces antidepressant and anxiolytic behavioral effects in mice
Duman CH, Schlesinger L, Russell DS, Duman RS. Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice. Brain Research 2008, 1199: 148-158. PMID: 18267317, PMCID: PMC2330082, DOI: 10.1016/j.brainres.2007.12.047.Peer-Reviewed Original ResearchMeSH KeywordsAmitriptylineAnalysis of VarianceAnimalsAntidepressive Agents, TricyclicAnxietyBehavior, AnimalBrain-Derived Neurotrophic FactorDepressionDisease Models, AnimalEscape ReactionHelplessness, LearnedMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutMotor ActivityPain MeasurementPhysical Conditioning, AnimalReaction TimeSwimmingTime FactorsConceptsBrain-derived neurotrophic factorAntidepressant-like behavioral responsesAntidepressant-like behavioral changesHeterozygous BDNF knockout miceBDNF knockout miceAntidepressant drug treatmentAntidepressant-like behaviorWheel-running exerciseDrug-treated animalsWild-type miceAnxiolytic behavioral effectsFST performanceSedentary control miceBDNF mRNASubchronic administrationChronic exerciseControl miceNeurotrophic factorBasic research studiesBehavioral responsesVoluntary exerciseBDNF geneDrug treatmentKnockout miceLocomotor activity
2006
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman CH, Schlesinger L, Kodama M, Russell DS, Duman RS. A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment. Biological Psychiatry 2006, 61: 661-670. PMID: 16945347, DOI: 10.1016/j.biopsych.2006.05.047.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAniline CompoundsAnimalsAntidepressive AgentsBehavior, AnimalBenzamidesBrain-Derived Neurotrophic FactorDepressionDisease Models, AnimalDose-Response Relationship, DrugDrug InteractionsEnzyme InhibitorsHelplessness, LearnedHindlimb SuspensionMaleMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase KinasesMotor ActivitySignal TransductionSwimmingConceptsBrain-derived neurotrophic factorAntidepressant-like effectsAntidepressant treatmentSwim testBDNF heterozygous knockout miceDepressive-like behaviorDepressive-like phenotypeTail suspension testEffects of desipramineHeterozygous knockout miceDepressive behavioral phenotypeEffect of inhibitionRodent behavioral modelsMouse behavioral modelsHeterozygous gene deletionAntidepressant mechanismAcute administrationAcute blockadeNeurotrophic factorAntidepressant drugsSuspension testDepressive phenotypeKnockout miceMEK inhibitionMEK inhibitorsTNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting
Simen BB, Duman CH, Simen AA, Duman RS. TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting. Biological Psychiatry 2006, 59: 775-785. PMID: 16458261, DOI: 10.1016/j.biopsych.2005.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnxietyBehavior, AnimalConditioning, PsychologicalDepressionDisease Models, AnimalDrinking BehaviorExploratory BehaviorFearGene ExpressionMaze LearningMiceMice, Inbred C57BLMice, KnockoutMotor ActivityReaction TimeReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionSucroseSwimmingTumor Necrosis Factor Decoy ReceptorsTumor Necrosis Factor-alphaConceptsPro-inflammatory cytokinesAntidepressant-like responseDepression-like behaviorDepression-like symptomsDeletion of TNFR1Acute injectionSerum levelsSwim testDepressed patientsMajor depressionReceptor subtypesSickness behaviorWildtype littermatesDepressive symptomsDrinking testPsychiatric conditionsCytokinesReceptor targetingSymptomsFear conditioningPatientsTNFalphaExploratory behaviorMiceBehavioral consequences
2003
Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine
Peakman M, Colby C, Perrotti L, Tekumalla P, Carle T, Ulery P, Chao J, Duman C, Steffen C, Monteggia L, Allen M, Stock J, Duman R, McNeish J, Barrot M, Self D, Nestler E, Schaeffer E. Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Research 2003, 970: 73-86. PMID: 12706249, DOI: 10.1016/s0006-8993(03)02230-3.Peer-Reviewed Original ResearchConceptsNucleus accumbensFos proteinAdult miceRewarding effectsTransgenic miceBrain regionsBrain region-specific expressionCocaine-induced locomotor activityTranscription factor nuclear factor-kappaBRegion-specific expressionAdministration of cocaineChronic drug administrationGlutamate receptor subunit GluR2Chronic cocaine administrationNuclear factor-kappaBProtein kinase Cdk5C-JunAP-1-mediated transcriptionCocaine administrationFos responsePlace preferenceSubunit GluR2Drug AdministrationFactor-kappaBLocomotor activity