TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting
Simen BB, Duman CH, Simen AA, Duman RS. TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting. Biological Psychiatry 2006, 59: 775-785. PMID: 16458261, DOI: 10.1016/j.biopsych.2005.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnxietyBehavior, AnimalConditioning, PsychologicalDepressionDisease Models, AnimalDrinking BehaviorExploratory BehaviorFearGene ExpressionMaze LearningMiceMice, Inbred C57BLMice, KnockoutMotor ActivityReaction TimeReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionSucroseSwimmingTumor Necrosis Factor Decoy ReceptorsTumor Necrosis Factor-alphaConceptsPro-inflammatory cytokinesAntidepressant-like responseDepression-like behaviorDepression-like symptomsDeletion of TNFR1Acute injectionSerum levelsSwim testDepressed patientsMajor depressionReceptor subtypesSickness behaviorWildtype littermatesDepressive symptomsDrinking testPsychiatric conditionsCytokinesReceptor targetingSymptomsFear conditioningPatientsTNFalphaExploratory behaviorMiceBehavioral consequences