2006
An FTIR investigation of isocyanate skin absorption using in vitro guinea pig skin
Bello D, Smith TJ, Woskie SR, Streicher RP, Boeniger MF, Redlich CA, Liu Y. An FTIR investigation of isocyanate skin absorption using in vitro guinea pig skin. Environmental Science Processes & Impacts 2006, 8: 523-529. PMID: 16688353, DOI: 10.1039/b517948c.Peer-Reviewed Original ResearchConceptsMethylenediphenyl diisocyanateIsocyanate groupsTotal reflectance Fourier transformReflectance Fourier transformHexamethylene diisocyanate isocyanurateTotal isocyanate groupFTIR investigationAromatic isocyanatesGuinea pig skinChemical groupsIsocyanatesUnreacted speciesSmall compoundsUnreacted compoundsDermal exposureEthyl acetateIsocyanurateHairless guinea pig skinPig skinCompoundsSkin surfaceContact dermatitisDecontamination strategiesResidence timeSkin absorption
2002
Effects of hexamethylene diisocyanate exposure on human airway epithelial cells: in vitro cellular and molecular studies.
Wisnewski AV, Liu Q, Miller JJ, Magoski N, Redlich CA. Effects of hexamethylene diisocyanate exposure on human airway epithelial cells: in vitro cellular and molecular studies. Environmental Health Perspectives 2002, 110: 901-907. PMID: 12204825, PMCID: PMC1240990, DOI: 10.1289/ehp.02110901.Peer-Reviewed Original ResearchConceptsHuman airway epithelial cellsImmunofluorescence analysisAirway epithelial cellsEpithelial cellsThiol redox homeostasisThioredoxin reductase expressionCellular stressEpithelial cell lineSensitive genesMicroarray analysisNorthern analysisHexamethylene diisocyanate exposureGenesAirway epithelial cell lineMolecular levelMolecular studiesDihydrodiol dehydrogenaseReductase expressionHDI exposureSubcytotoxic concentrationsCell linesMessage levelsImportant sensorMRNA levelsCells