2020
Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology
Wisnewski AV, Liu J, Redlich CA. Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology. American Journal Of Respiratory Cell And Molecular Biology 2020, 0: 25-35. PMID: 32101465, PMCID: PMC7328250, DOI: 10.1165/rcmb.2019-0400oc.Peer-Reviewed Original ResearchConceptsRespiratory tract exposureAirway eosinophiliaMonocytes/macrophagesMouse modelGene expressionGene transcriptsBiological pathwaysAsthma pathologyUpregulated gene transcriptsIgE-independent mechanismsLung gene expressionLung tissue gene expressionCause of asthmaBALB/cTransgenic B cellsTissue gene expressionExpression changesDiisocyanate asthmaSensitized workersAsthma pathogenesisAirway fluidDeficient miceMRNA microarrayEosinophiliaB cells
2007
Cost‐Effectiveness of Various Diagnostic Approaches for Occupational Asthma
Kennedy WA, Girard F, Chaboillez S, Cartier A, Côté J, Hargreave F, Labrecque M, Malo JL, Tarlo SM, Redlich CA, Lemière C. Cost‐Effectiveness of Various Diagnostic Approaches for Occupational Asthma. Canadian Respiratory Journal 2007, 14: 276-280. PMID: 17703242, PMCID: PMC2676393, DOI: 10.1155/2007/206519.Peer-Reviewed Original ResearchConceptsSpecific inhalation challengeOccupational asthmaSputum testingProbabilistic sensitivity analysesPEF monitoringDiagnosis of OASputum cell countsProportion of eosinophilsExpiratory flow monitoringAdditional correct diagnosisBase-case analysisInhalation challengeClinical outcomesOA patientsTreeAge ProClinical dataSerial measurementsCorrect diagnosisPatientsCanadian hospitalsCell countDiagnostic approachGold standardDiagnosisCost-effective alternative