IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury.
Redlich C, Gao X, Rockwell S, Kelley M, Elias J. IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. The Journal Of Immunology 1996, 157: 1705-10. PMID: 8759759, DOI: 10.4049/jimmunol.157.4.1705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchoalveolar Lavage FluidCell LineGene Expression RegulationGene Expression Regulation, NeoplasticInjections, SubcutaneousInterleukin-11Lung NeoplasmsMacrophages, AlveolarMiceMice, Inbred BALB CNeoplasm ProteinsNeoplastic Stem CellsRadiation Injuries, ExperimentalRecombinant ProteinsRNA, MessengerRNA, NeoplasmSpecific Pathogen-Free OrganismsThoracic InjuriesTumor Necrosis Factor-alphaConceptsThoracic irradiationThoracic injuriesControl miceTNF protein productionTNF productionVehicle-treated control miceNormal thoracic structuresPulmonary metastatic tumorsEMT6 tumor cellsTNF mRNA expressionDose of radiationLung metastasesInhibits LPSMetastatic tumorsNormal lungRadioprotective effectMRNA expressionIL-11Enhances SurvivalTumor cellsObserved protectionSignificant radioprotectionTNF mRNAThoracic structuresStudy interval