2008
Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI–albumin conjugates
Wisnewski AV, Liu Q, Liu J, Redlich CA. Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI–albumin conjugates. Clinical & Experimental Allergy 2008, 38: 957-967. PMID: 18498542, PMCID: PMC3131007, DOI: 10.1111/j.1365-2222.2008.02982.x.Peer-Reviewed Original ResearchMeSH KeywordsAdipokinesAdministration, InhalationAlbuminsAntigens, CDBlotting, WesternCells, CulturedChemokine CCL2Chitinase-3-Like Protein 1ChitinasesCyanatesEnzyme-Linked Immunosorbent AssayGene ExpressionGlycoproteinsHumansImmunity, InnateIntramolecular OxidoreductasesIsocyanatesLectinsLeukocytes, MononuclearLysosomesMacrophage Migration-Inhibitory FactorsMicroscopy, FluorescenceOligonucleotide Array Sequence AnalysisPolymerase Chain ReactionPolymorphism, GeneticProteinsRNAConceptsPeripheral blood mononuclear cellsInnate immune responseImmune responsePercentage of PBMCHuman peripheral blood mononuclear cellsFlow cytometrySystemic innate immune responseExposure-dependent decreaseMonocyte/macrophage traffickingHuman innate immune responseProtein expressionSpecific inhalation challengeBlood mononuclear cellsAdaptive immune responsesLow-density lipoproteinPattern recognition receptorsInhalation challengeOccupational asthmaClinical spectrumControl antigenMononuclear cellsHDI exposureSerum concentrationsAdaptive immunityGene/protein expression
1990
Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction.
Omiecinski C, Redlich C, Costa P. Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction. Cancer Research 1990, 50: 4315-21. PMID: 1694720.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsBase SequenceBlotting, NorthernBlotting, SouthernCytochrome P-450 Enzyme SystemDNAGene Expression Regulation, EnzymologicGenesIsoenzymesLiverMethylcholanthreneMolecular Sequence DataOligonucleotide ProbesOrgan SpecificityPhenobarbitalPolymerase Chain ReactionRatsRats, Inbred StrainsReference ValuesRNARNA, MessengerConceptsPolymerase chain reactionHuman pulmonary alveolar macrophagesChain reactionP450IA1 mRNAEarly gestational stageEnvironmental chemical exposuresPulmonary alveolar macrophagesDevelopmental ageTransplacental treatmentFetal ratsHuman gestationGestational stagesRat lungAlveolar macrophagesDay 15Related cancersHuman tissue samplesIndividual susceptibilityDay 45Fetal liver developmentTarget cellsMRNA expression patternsRatsTissue samplesChemical exposure