2022
Assessment of personal inhalation and skin exposures to polymeric methylene diphenyl diisocyanate during polyurethane fabric coating
Harari H, Bello D, Woskie S, Redlich CA. Assessment of personal inhalation and skin exposures to polymeric methylene diphenyl diisocyanate during polyurethane fabric coating. Toxicology And Industrial Health 2022, 38: 622-635. PMID: 35694796, DOI: 10.1177/07482337221107243.Peer-Reviewed Original ResearchConceptsSkin exposurePersonal inhalationOccupational asthmaHypersensitivity pneumonitisContact dermatitisInitial sensitizationWork exposureArea air samplesInhalation exposureOccupational limitsLiquid chromatography-tandem mass spectrometryHealth effects studiesHealth effectsPersonal airborne samplesGeometric meanChromatography-tandem mass spectrometryExposure characterizationInhalationExposureFuture studiesGreater exposureAirborne levelsSubstantial variabilityProtective measuresGeometric standard deviation
2021
Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory
Wisnewski AV, Redlich CA. Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory. American Journal Of Industrial Medicine 2021, 64: 1055-1056. PMID: 34647343, DOI: 10.1002/ajim.23299.Commentaries, Editorials and Letters
2014
Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up
Gui W, Wisnewski AV, Neamtiu I, Gurzau E, Sparer JA, Stowe MH, Liu J, Slade MD, Rusu OA, Redlich CA. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up. American Journal Of Industrial Medicine 2014, 57: 1207-1215. PMID: 25266741, PMCID: PMC4198484, DOI: 10.1002/ajim.22385.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAirway ObstructionAsthma, OccupationalFemaleFollow-Up StudiesForced Expiratory VolumeHumansImmunoglobulin EImmunoglobulin GLost to Follow-UpMaleMiddle AgedOccupational ExposurePolyurethanesPrevalenceProspective StudiesTime FactorsToluene 2,4-DiisocyanateVital CapacityYoung AdultConceptsAsthma symptomsIsocyanate asthmaInception cohort studyHealth effectsCurrent asthma symptomsTDI levelsFirst yearFurther longitudinal evaluationAirflow obstructionCohort studyInception cohortOccupational asthmaTDI exposureRespiratory healthSkin exposureLongitudinal evaluationAsthmaOne-yearPersonal samplingSymptomsRiskExposureFindingsFEV1Spirometry
2012
Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG
Wisnewski AV, Stowe MH, Nerlinger A, Opare-addo P, Decamp D, Kleinsmith CR, Redlich CA. Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG. Annals Of Work Exposures And Health 2012, 56: 901-910. PMID: 22449630, PMCID: PMC3471419, DOI: 10.1093/annhyg/mes024.Peer-Reviewed Original ResearchConceptsPersonal protective equipmentSkin exposureExposure surveillanceSpecific serum immunoglobulin GHexamethylene diisocyanate exposureSerum IgG levelsSerum immunoglobulin GNight shift workEnzyme-linked immunosorbentAdverse health effectsAsthma historyDiisocyanate exposureIgG levelsSerum levelsIgG titersChemical allergensPPE useImmune responseRespirator useIsocyanate exposureExposure biomarkersPractical biomarkersBasic demographicsHigh titersHygiene efforts
2008
Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: III. A Personal Exposure Algorithm
Liu Y, Stowe MH, Bello D, Sparer J, Gore RJ, Cullen MR, Redlich CA, Woskie SR. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: III. A Personal Exposure Algorithm. Annals Of Work Exposures And Health 2008, 53: 33-40. PMID: 19011126, PMCID: PMC2638551, DOI: 10.1093/annhyg/men070.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAutomobilesEnvironmental MonitoringHumansOccupational ExposurePolyurethanesSkinConceptsPersonal protective equipmentSkin exposureExposure metricsAuto body shop workersExposure indexUse of PPEExposure-response relationshipJob title categoriesAuto Body RepairIsocyanate asthmaExposure algorithmSemiquantitative algorithmSkin areasProtective equipmentSuch exposureExposure dataSpearman correlationShop workersExposure indicatorsOffice workersPositive Spearman correlationAuto body shopsExposureTask-based dataWork diariesSkin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: II. A Quantitative Assessment
Bello D, Redlich CA, Stowe MH, Sparer J, Woskie SR, Streicher RP, Hosgood HD, Liu Y. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: II. A Quantitative Assessment. Annals Of Work Exposures And Health 2008, 52: 117-124. PMID: 18209009, DOI: 10.1093/annhyg/mem066.Peer-Reviewed Original ResearchConceptsSkin exposureUnprotected skinAuto body shop workersAuto Body RepairRespiratory exposureSkin areasExposure dataShop workersSkin samplingSkinExposureWipe samplesUnpaired samplesHigh concentrationsPPEGm loadYale studyHigh levelsBody repairAsthmaMajor contributorLevelsQuantitative assessmentForearmSensitization
2007
Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: A Qualitative Assessment
LIU Y, BELLO D, SPARER JA, STOWE MH, GORE RJ, WOSKIE SR, CULLEN MR, REDLICH CA. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: A Qualitative Assessment. Annals Of Work Exposures And Health 2007, 51: 429-439. PMID: 17602207, DOI: 10.1093/annhyg/mem021.Peer-Reviewed Original ResearchConceptsAuto body shop workersSkin exposureHigh-performance liquid chromatographyShop workersHigher positive rateAuto Body RepairPositive surface samplesPositive sample rateEpidemiologic studiesUnprotected skinRespiratory exposurePercent of samplesSensitive high-performance liquid chromatographyLatex glovesScale 0Exposure dataExposure determinantsSkin samplesQuantitative high-performance liquid chromatographyNational InstituteOccupational SafetyAuto body shopsExposureMajor determinantPositive rateSlow Curing of Aliphatic Polyisocyanate Paints in Automotive Refinishing: A Potential Source for Skin Exposure
Bello D, Sparer J, Redlich CA, Ibrahim K, Stowe MH, Liu Y. Slow Curing of Aliphatic Polyisocyanate Paints in Automotive Refinishing: A Potential Source for Skin Exposure. Journal Of Occupational And Environmental Hygiene 2007, 4: 406-411. PMID: 17474030, DOI: 10.1080/15459620701341199.Peer-Reviewed Original Research
1990
Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide
Redlich C, West A, Fleming L, True L, Cullen M, Riely C. Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide. Gastroenterology 1990, 99: 748-757. PMID: 2379779, DOI: 10.1016/0016-5085(90)90964-3.Peer-Reviewed Original ResearchConceptsToxic liver injuryLiver injuryDisulfiram-type reactionsFocal hepatocellular necrosisSmooth endoplasmic reticulumProminent smooth endoplasmic reticulumAbnormal aminotransferasesAbdominal painBiopsy findingsClinical characteristicsEnzyme elevationLiver biopsyPleomorphic mitochondriaAcute injuryHepatocellular necrosisMicrovesicular steatosisBiopsy histologyMacrovesicular steatosisPathological characteristicsOccupational exposureAlanine aminotransferaseOccupational historyLonger exposureInjuryAminotransferase
1988
Liver disease associated with occupational exposure to the solvent dimethylformamide.
Redlich C, Beckett W, Sparer J, Barwick K, Riely C, Miller H, Sigal S, Shalat S, Cullen M. Liver disease associated with occupational exposure to the solvent dimethylformamide. Annals Of Internal Medicine 1988, 108: 680-6. PMID: 3358569, DOI: 10.7326/0003-4819-108-5-680.Peer-Reviewed Original ResearchConceptsToxic liver diseaseLiver enzyme abnormalitiesLiver diseaseEnzyme abnormalitiesAspartate aminotransferaseALT levelsBiopsy specimensStandard liver function testsAppropriate skin protectionClinical-epidemiological investigationNegative viral serologyOccupational liver diseaseSymptoms of hepatitisEnzyme levelsLiver function testsLiver biopsy specimensRatio of ASTToxic liver injuryOccupational medicine clinicExtensive clinical evaluationAcademic medical centerViral serologyAminotransferase levelsMost patientsLiver injury