2005
Glutathione protects human airway proteins and epithelial cells from isocyanates
Wisnewski AV, Liu Q, Liu J, Redlich CA. Glutathione protects human airway proteins and epithelial cells from isocyanates. Clinical & Experimental Allergy 2005, 35: 352-357. PMID: 15784115, DOI: 10.1111/j.1365-2222.2005.02185.x.Peer-Reviewed Original ResearchConceptsDose-dependent mannerAirway fluidGSH levelsHuman airway epithelial cellsVapor exposure systemEpithelial cellsHuman airway epithelial cell lineAirway epithelial cell lineEpithelial lining fluidAirway epithelial cellsEpithelial cell exposureEpithelial cell toxicityAllergic sensitizationEpithelial cell lineHDI exposureAirway proteinsLining fluidAirway cellsIsocyanate exposureVivo exposureOccupational limitsNCI-H292Physiologic levelsEpithelial fluidToxicity studies
2000
Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo
WISNEWSKI A, SRIVASTAVA R, HERICK C, XU L, LEMUS R, CAIN H, MAGOSKI N, KAROL M, BOTTOMLY K, REDLICH C. Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo. American Journal Of Respiratory And Critical Care Medicine 2000, 162: 2330-2336. PMID: 11112159, DOI: 10.1164/ajrccm.162.6.2002086.Peer-Reviewed Original ResearchConceptsDiisocyanate-induced asthmaBiopsy samplesHuman lungHuman airway epithelial cellsBronchoalveolar lavage fluidAirway epithelial cellsEndobronchial biopsy samplesHuman skin biopsy samplesSkin biopsy samplesKeratin 18Epicutaneous exposureLavage fluidSkin proteinsVivo inhalationVivo exposureEpithelial cell proteinsGlucose-regulated proteinEpithelial cellsAsthmaLungExposureVitroVivoKeratinCell proteins