2011
Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs
Rockwell S, Liu Y, Mayne ST, Redlich CA. Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs. Experimental Biology And Medicine 2011, 236: 1173-1179. PMID: 21844122, PMCID: PMC3207150, DOI: 10.1258/ebm.2011.011082.Peer-Reviewed Original ResearchConceptsWhole lung irradiationSubclinical vitaminSpontaneous lung metastasesLung metastasesLung tumorsVitamin ALung irradiationTumor cellsLow vitaminDeficient dietSubcutaneous tumorsPossible modifiable risk factorsSeverity of pneumonitisModifiable risk factorsRadiation-induced pneumonitisEnhancement of metastasisImpact of vitaminDose-dependent increaseLevels of retinolGrowth of tumorsDevelopment of tumorsDose-response curveLung injuryLung levelsPrimary cancer
2005
Changes in cholesterol and triglyceride concentrations in the Vanguard population of the Carotene and Retinol Efficacy Trial (CARET)
Cartmel B, Dziura J, Cullen MR, Vegso S, Omenn GS, Goodman GE, Redlich CA. Changes in cholesterol and triglyceride concentrations in the Vanguard population of the Carotene and Retinol Efficacy Trial (CARET). European Journal Of Clinical Nutrition 2005, 59: 1173-1180. PMID: 16015255, DOI: 10.1038/sj.ejcn.1602229.Peer-Reviewed Original ResearchConceptsRetinol Efficacy TrialPlacebo armSerum triglyceridesTriglyceride concentrationsEfficacy trialsVitamin ASerum cholesterol concentrationActive intervention armsActive intervention groupNational Cancer InstituteCardiovascular deathPlacebo groupCardiovascular mortalitySerum lipidsTotal cholesterolIntervention armSerum cholesterolVanguard StudyLung cancerIntervention groupCardiovascular diseaseCancer InstituteCholesterol concentrationsActive armBeta carotene
1999
Erratum to “Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy trial (CARET)” [Atherosclerosis 143 (1999) 427–434]
Redlich C, Chung J, Cullen M, Blaner W, Van Bennekum A, Berglund L. Erratum to “Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy trial (CARET)” [Atherosclerosis 143 (1999) 427–434]. Atherosclerosis 1999, 145: 423. DOI: 10.1016/s0021-9150(99)00270-1.Peer-Reviewed Original Research
1998
Vitamin A Inhibits Radiation-Induced Pneumonitis in Rats 1 , 2
Redlich C, Rockwell S, Chung J, Sikora A, Kelley M, Mayne S. Vitamin A Inhibits Radiation-Induced Pneumonitis in Rats 1 , 2. Journal Of Nutrition 1998, 128: 1661-1664. PMID: 9772133, DOI: 10.1093/jn/128.10.1661.Peer-Reviewed Original ResearchConceptsRadiation-induced lung injuryVitamin ALung injuryLung inflammationRadiation-induced lung inflammationLung retinol levelsSupplemental vitamin AAltered vitaminThoracic radiationThoracic radiotherapyBronchoalveolar lavagePrescribed dietRetinol levelsDeficient groupDeficient dietTotal doseY ratsRadioprotective agentsRats 1RatsWhole thoraxHost susceptibilityDietInflammationInjuryDietary vitamin A and prevalence of bronchial metaplasia in asbestos-exposed workers 1 2 3
Mayne ST, Redlich CA, Cullen MR. Dietary vitamin A and prevalence of bronchial metaplasia in asbestos-exposed workers 1 2 3. American Journal Of Clinical Nutrition 1998, 68: 630-636. PMID: 9734740, DOI: 10.1093/ajcn/68.3.630.Peer-Reviewed Original ResearchConceptsTotal vitamin ABronchial metaplasiaVitamin AAsbestos workersDietary intakeHigh intakeBronchial squamous metaplasiaGreater airway obstructionPulmonary function testingDietary vitamin ALogistic regression analysisAirway obstructionFormer smokingCurrent smokingBronchial biopsiesTobacco exposureSquamous metaplasiaFunction testingAsbestos exposureForm of retinolNonsignificant reductionLow intakeMetaplasiaNonsignificant increaseIndustrial clinicsEffect of supplementation with beta-carotene and vitamin A on lung nutrient levels.
Redlich CA, Blaner WS, Van Bennekum AM, Chung JS, Clever SL, Holm CT, Cullen MR. Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels. Cancer Epidemiology Biomarkers & Prevention 1998, 7: 211-4. PMID: 9521435.Peer-Reviewed Original ResearchConceptsActive armRetinol levelsLung tissueExcess lung cancer mortalityLung cancer chemoprevention trialsLung retinol levelsRetinol Efficacy TrialLung tissue levelsLung cancer mortalityCancer chemoprevention trialsEffect of supplementationLung retinolChemoprevention trialsCancer mortalitySurgical controlEfficacy trialsCell levelVitamin ARetinyl palmitateSame interventionTissue levelsBiomarker studiesSupplementationInterventionTrials
1996
Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages.
Redlich CA, Grauer JN, Van Bennekum AM, Clever SL, Ponn RB, Blaner WS. Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages. American Journal Of Respiratory And Critical Care Medicine 1996, 154: 1436-1443. PMID: 8912761, DOI: 10.1164/ajrccm.154.5.8912761.Peer-Reviewed Original ResearchConceptsLung tissue levelsHuman lung tissueBAL cellsLung tissueAlpha-tocopherolTissue levelsSerum levelsHigh-pressure liquid chromatographyBronchoalveolar lavage cellsOpen lung surgeryFresh lung tissueImportant protective effectDietary questionnaireLung surgeryLavage cellsProtective effectPulmonary macrophagesReverse-phase high-pressure liquid chromatographyVitamin AHuman lungDietary levelsPotential markerRetinolSerumPatients
1995
Vitamin A Chemoprevention of Lung Cancer
Redlich C, Van Bennekum A, Wirth J, Blaner W, Carter D, Tanoue L, Holm C, Cullen M. Vitamin A Chemoprevention of Lung Cancer. Advances In Experimental Medicine And Biology 1995, 375: 17-29. PMID: 7645426, DOI: 10.1007/978-1-4899-0949-7_2.Peer-Reviewed Original ResearchConceptsLung cancerParenchymal fibrosisVitamin ABronchoalveolar lavageHigh riskAsbestos-exposed subjectsDouble-blind placeboDietary vitamin ASupplemental vitamin AEffective preventive strategiesPrior clinical studiesPotential early markerProcess of inflammationBiomarkers of susceptibilityBronchial metaplasiaLung inflammationPulmonary cytokinesBronchial biopsiesImmunomodulatory effectsClinical studiesPreventive strategiesHost determinantsHigh incidenceEarly markerFibrosis
1994
Association Between Dietary Vitamin A Intake and Bronchial Metaplasia in Asbestos Exposed Workers
Redlich C, Mohr S, Mayne S, Merrill W, Carter D, Cullen M. Association Between Dietary Vitamin A Intake and Bronchial Metaplasia in Asbestos Exposed Workers. Advances In Experimental Medicine And Biology 1994, 375: 241-241. DOI: 10.1007/978-1-4899-0939-8_41.Peer-Reviewed Original Research