2017
Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy
Wisnewski AV, Kanyo J, Asher J, Goodrich JA, Barnett G, Patrylak L, Liu J, Redlich CA, Nassar AF. Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy. Xenobiotica 2017, 48: 488-497. PMID: 28489470, PMCID: PMC5863241, DOI: 10.1080/00498254.2017.1329569.Peer-Reviewed Original ResearchConceptsCollision-induced dissociation (CID) fragmentation patternsReaction productsLower airwaysChemical reactivityLow molecular weight fractionWeight fractionHigh molecular weight fractionAliphatic diisocyanateMolecular weight fractionFragmentation patternsHexamethylenediisocyanateLC-MSHDI vaporAirways of rabbitsBronchoalveolar lavage fluidRabbit bronchoalveolar lavage fluidMoleculesDiisocyanate vaporsMs. 4Albumin. 5Occupational asthmaReactivityBAL fluidAsthma pathogenesisLavage fluid
2002
Diisocyanate asthma: clinical aspects and immunopathogenesis
Redlich CA, Karol MH. Diisocyanate asthma: clinical aspects and immunopathogenesis. International Immunopharmacology 2002, 2: 213-224. PMID: 11811926, DOI: 10.1016/s1567-5769(01)00174-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDiisocyanate asthmaProduction of polyurethanesChemical reactivityBiological nucleophilesClinical aspectsChemical interactionReactive chemicalsRoute of exposureDiisocyanateSimple diagnostic testOccupational asthmaEarly diseaseRespiratory tractNonimmunological mechanismsWorkplace exposuresAsthmaUseful markerReactionDiagnostic testsDiseasePathogenesisImmunopathogenesisBiomoleculesNucleophilesExposure