1998
Dietary vitamin A and prevalence of bronchial metaplasia in asbestos-exposed workers 1 2 3
Mayne ST, Redlich CA, Cullen MR. Dietary vitamin A and prevalence of bronchial metaplasia in asbestos-exposed workers 1 2 3. American Journal Of Clinical Nutrition 1998, 68: 630-636. PMID: 9734740, DOI: 10.1093/ajcn/68.3.630.Peer-Reviewed Original ResearchConceptsTotal vitamin ABronchial metaplasiaVitamin AAsbestos workersDietary intakeHigh intakeBronchial squamous metaplasiaGreater airway obstructionPulmonary function testingDietary vitamin ALogistic regression analysisAirway obstructionFormer smokingCurrent smokingBronchial biopsiesTobacco exposureSquamous metaplasiaFunction testingAsbestos exposureForm of retinolNonsignificant reductionLow intakeMetaplasiaNonsignificant increaseIndustrial clinics
1997
Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate.
Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR. Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate. Scandinavian Journal Of Work, Environment & Health 1997, 23: 227-31. PMID: 9243734, DOI: 10.5271/sjweh.203.Peer-Reviewed Original ResearchConceptsHuman bronchial biopsiesHuman lung tissueExposure-disease relationshipsAirway eosinophilsAirway histologyEpithelial exposureMethacholine challengeBronchial biopsiesEndobronchial biopsyInflammatory changesClinical featuresAirway biopsiesIsocyanate asthmaLung tissueT cellsImmunohistochemical stainingAsthmaBiopsyExposure patternsBronchoscopyExposureAirwayPatientsEosinophilsHistology
1995
Vitamin A Chemoprevention of Lung Cancer
Redlich C, Van Bennekum A, Wirth J, Blaner W, Carter D, Tanoue L, Holm C, Cullen M. Vitamin A Chemoprevention of Lung Cancer. Advances In Experimental Medicine And Biology 1995, 375: 17-29. PMID: 7645426, DOI: 10.1007/978-1-4899-0949-7_2.Peer-Reviewed Original ResearchConceptsLung cancerParenchymal fibrosisVitamin ABronchoalveolar lavageHigh riskAsbestos-exposed subjectsDouble-blind placeboDietary vitamin ASupplemental vitamin AEffective preventive strategiesPrior clinical studiesPotential early markerProcess of inflammationBiomarkers of susceptibilityBronchial metaplasiaLung inflammationPulmonary cytokinesBronchial biopsiesImmunomodulatory effectsClinical studiesPreventive strategiesHost determinantsHigh incidenceEarly markerFibrosis