1992
Drug-responsive symptoms during early neuroleptic treatment
Mazure C, Nelson J, Jatlow P, Bowers M. Drug-responsive symptoms during early neuroleptic treatment. Psychiatry Research 1992, 41: 147-154. PMID: 1574541, DOI: 10.1016/0165-1781(92)90106-d.Peer-Reviewed Original ResearchConceptsDrug responseEarly drug responseDays of treatmentIdentification of symptomsNeuroleptic treatmentSerum concentrationsNeuroleptic drugsNeurochemical mechanismsPositive symptomsSymptomsProgressive phaseDrug actionConceptual disorganizationMultiple regression analysisRegression analysisTreatmentPsychosisSeverityHallucinationsResponse
1990
The relationship between blood perphenazine levels, early resolution of psychotic symptoms, and side effects.
Mazure CM, Nelson JC, Jatlow PI, Kincare P, Bowers MB. The relationship between blood perphenazine levels, early resolution of psychotic symptoms, and side effects. The Journal Of Clinical Psychiatry 1990, 51: 330-4. PMID: 2199431.Peer-Reviewed Original ResearchMeSH KeywordsAdultAkathisia, Drug-InducedBasal Ganglia DiseasesBenztropineClinical Trials as TopicDose-Response Relationship, DrugDrug Administration ScheduleFemaleHospitalizationHumansMaleParkinson Disease, SecondaryPerphenazinePsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyConceptsExtrapyramidal side effectsSide effectsBrief Psychiatric Rating Scale (BPRS) totalSerious extrapyramidal side effectsIndividual BPRS itemsResolution of psychosisEarly resolutionBlood level monitoringBlood levelsIndividual symptomsTherapeutic thresholdPsychotic symptomsPsychotic inpatientsScale totalDrug efficacyBPRS itemsPerphenazine concentrationSymptomsPsychosisPerphenazineLevel monitoring