Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents
Lippard ET, Mazure CM, Johnston JA, Spencer L, Weathers J, Pittman B, Wang F, Blumberg HP. Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents. Journal Of Neuroscience Research 2016, 95: 777-791. PMID: 27870392, PMCID: PMC5123602, DOI: 10.1002/jnr.23901.Peer-Reviewed Original ResearchConceptsGray matter volumePrefrontal gray matter volumeBipolar disorderSubstance use problemsFuture substance useSubstance useLower gray matter volumeUse problemsFuture substance use problemsRegional gray matter volumeStructural magnetic resonanceAdverse outcomesTemporopolar cortexInsula gray matter volumeSubstance exposureMood disordersHigh riskLower riskSubsequent alcoholMatter volumeNeurodevelopmental basisSubstance problemsDisordersAdolescentsMales