2011
Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model
Macica C, Liang G, Nasiri A, Broadus AE. Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model. Arthritis & Rheumatism 2011, 63: 3333-3343. PMID: 21702022, PMCID: PMC3197958, DOI: 10.1002/art.30515.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArthritis, ExperimentalCartilage, ArticularChondrocytesDisease ProgressionMaleMiceMice, KnockoutParathyroid Hormone-Related ProteinConceptsHormone-related proteinDegenerative changesKO miceParathyroid hormone-related proteinMale KO miceExperimental mouse modelMouse articular cartilageTotal histologic scoreIndian hedgehogTibial articular surfaceArticular chondrocytesArticular cartilageGrowth differentiation factor 5Degenerative findingsControl miceHistologic scoresMouse modelCompensatory increaseTime-course studyDifferentiation factor 5PTHrPRegulatory roleMiceConditional deletionChondrocyte maintenanceAn Atypical Degenerative Osteoarthropathy in Hyp Mice is Characterized by a Loss in the Mineralized Zone of Articular Cartilage
Liang G, VanHouten J, Macica C. An Atypical Degenerative Osteoarthropathy in Hyp Mice is Characterized by a Loss in the Mineralized Zone of Articular Cartilage. Calcified Tissue International 2011, 89: 151-162. PMID: 21643724, DOI: 10.1007/s00223-011-9502-4.Peer-Reviewed Original Research
2008
Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone–related protein in mice
Chen X, Macica CM, Nasiri A, Broadus AE. Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone–related protein in mice. Arthritis & Rheumatism 2008, 58: 3788-3797. PMID: 19035497, PMCID: PMC2599803, DOI: 10.1002/art.23985.Peer-Reviewed Original ResearchConceptsPTHrP expressionParathyroid hormone-related proteinArticular cartilagePTHrP-knockout micePathogenesis of arthritisWeight-bearing jointsHormone-related proteinChondrocyte proliferationIndian hedgehogGrowth plate structureCell of originArticular chondrocytesEpiphyseal growth zoneSecondary ossification centerArticular chondrocyte differentiationArticular chondrocyte proliferationAdult miceAxis participatesKnockin miceMicePTHrPProtein axisOssification centersIhhCartilage
2007
The PTHrP Functional Domain Is at the Gates of Endochondral Bones
BROADUS AE, MACICA C, CHEN X. The PTHrP Functional Domain Is at the Gates of Endochondral Bones. Annals Of The New York Academy Of Sciences 2007, 1116: 65-81. PMID: 18083922, DOI: 10.1196/annals.1402.061.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone DevelopmentCartilage, ArticularLac OperonMiceParathyroid Hormone-Related ProteinConceptsGene expression productsEndochondral boneGene regulation experimentsFunctional domainsBone cell populationsMesenchymal condensationLow abundanceChondrocyte populationsKnockin miceCell populationsGrowth plate cartilageUnrecognized siteInsertion siteExpressionEpiphyseal cartilageSitesLacZAbundance