Stretch‐Induced PTH‐Related Protein Gene Expression in Osteoblasts*
Chen X, Macica CM, Ng KW, Broadus AE. Stretch‐Induced PTH‐Related Protein Gene Expression in Osteoblasts*. Journal Of Bone And Mineral Research 2005, 20: 1454-1461. PMID: 16007342, DOI: 10.1359/jbmr.2005.20.8.1454.Peer-Reviewed Original ResearchConceptsAnabolic effectsStretch-activated potassium channelsCandidate mediatorsCyclical stretchPotassium channelsL-type calcium channelsN-terminal PTHPTHrP mRNA expressionStretch-activated cation channelsSmooth muscle cellsOsteoblast-like cellsUMR 201PTHrP gene expressionHypotonic solutionEndogenous mediatorsPTHrP mRNAIntracellular acidosisExtracellular calciumCalcium channelsFlexercell apparatusPTHrPRNase protection assaysMRNA expressionMuscle cellsSkeletal mass