The PTHrP Functional Domain Is at the Gates of Endochondral Bones
BROADUS AE, MACICA C, CHEN X. The PTHrP Functional Domain Is at the Gates of Endochondral Bones. Annals Of The New York Academy Of Sciences 2007, 1116: 65-81. PMID: 18083922, DOI: 10.1196/annals.1402.061.Peer-Reviewed Original ResearchConceptsGene expression productsEndochondral boneGene regulation experimentsFunctional domainsBone cell populationsMesenchymal condensationLow abundanceChondrocyte populationsKnockin miceCell populationsGrowth plate cartilageUnrecognized siteInsertion siteExpressionEpiphyseal cartilageSitesLacZAbundanceMechanical regulation of PTHrP expression in entheses
Chen X, Macica C, Nasiri A, Judex S, Broadus AE. Mechanical regulation of PTHrP expression in entheses. Bone 2007, 41: 752-759. PMID: 17869201, PMCID: PMC2219696, DOI: 10.1016/j.bone.2007.07.020.Peer-Reviewed Original ResearchConceptsMedial collateral ligamentPTHrP expressionSurgical transectionBone cell populationsTail suspensionType 1 PTH/PTHrP receptorCell populationsPTH/PTHrP receptorDetailed histological evaluationSitu hybridization histochemical techniquesDistinct temporospatial patternLigament insertion sitesMetaphyseal periosteumPTHrP receptorOsteoclastic activityCollateral ligamentHistological evaluationReporter miceKnockin miceInsertion siteKnockin reporter micePTHrPPTHrP geneCD-1Periosteum