2009
Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions
Fredericks CA, Drabant EM, Edge MD, Tillie JM, Hallmayer J, Ramel W, Kuo JR, Mackey S, Gross JJ, Dhabhar FS. Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. Brain Behavior And Immunity 2009, 24: 350-357. PMID: 19883751, PMCID: PMC2826575, DOI: 10.1016/j.bbi.2009.10.014.Peer-Reviewed Original ResearchConceptsPro-inflammatory biasTrier Social Stress TestLower anti-inflammatory cytokinesChronic pro-inflammatory stateIL-6/ILHigher IL-6/ILSerum IL-6Anti-inflammatory cytokinesPro-inflammatory stateHealthy young womenPro-inflammatory cytokinesSS individualsLife stressLow exposureStress testPromoter region polymorphismsIL-10IL-6Relevant biological effectsRecent life stressSocial Stress TestHealthy subjectsNeurobiological effectsClinical relevanceLL individuals
2008
Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder
Chepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder. Neuropsychopharmacology 2008, 34: 944-951. PMID: 18704093, PMCID: PMC2837582, DOI: 10.1038/npp.2008.107.Peer-Reviewed Original ResearchConceptsSmaller hippocampus volumesHippocampus volumeBipolar disorderBDNF genotypeBD diagnosisMood disorder pathophysiologyBDNF Val66Met polymorphismHigh-resolution magnetic resonanceHealthy comparison subjectsVal/Val homozygotesEffect of diagnosisLinear mixed model analysisVal66Met polymorphismGrowth factor proteinBD subgroupsDisorder pathophysiologyHC subjectsHippocampal developmentComparison subjectsMixed model analysisHippocampus structureBDNFHippocampus morphologyAnterior hippocampusVal homozygotes