2024
Chemical entity normalization for successful translational development of Alzheimer’s disease and dementia therapeutics
Mullin S, McDougal R, Cheung K, Kilicoglu H, Beck A, Zeiss C. Chemical entity normalization for successful translational development of Alzheimer’s disease and dementia therapeutics. Journal Of Biomedical Semantics 2024, 15: 13. PMID: 39080729, PMCID: PMC11290083, DOI: 10.1186/s13326-024-00314-1.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBiological OntologiesDementiaHumansNatural Language ProcessingTranslational Research, BiomedicalConceptsEntity normalizationChemical mentionsNatural language modelDictionary-based methodsDictionary-based approachCRAFT corpusDownstream tasksLanguage modelChemical Entities of Biological InterestPubMedBERT modelDisambiguationChEBIDownstream applicationsArticle abstractsRelationship typesMentionsPubMedBERTOntologyDementia literatureTaskDementia CohortMethodEntitiesAccuracyDementia
2020
Utility of spontaneous animal models of Alzheimer’s disease in preclinical efficacy studies
Zeiss CJ. Utility of spontaneous animal models of Alzheimer’s disease in preclinical efficacy studies. Cell And Tissue Research 2020, 380: 273-286. PMID: 32337614, DOI: 10.1007/s00441-020-03198-6.Peer-Reviewed Original ResearchConceptsHuman Alzheimer's diseaseSpontaneous animal modelAlzheimer's diseaseAnimal modelsBiomarker progressionProgression of neuropathologyLate-onset Alzheimer's diseasePreclinical efficacy studiesHuman clinical trialsOnset Alzheimer's diseaseUsable outcome measuresAD-associated mutationsFamilial Alzheimer's diseaseNon-human primatesAmyloid neuropathologyInterventional studyClinical trialsSpontaneous modelHuman trialsOutcome measuresTherapeutic successPotential therapyNew therapiesRodent studiesEfficacy studies
2014
Improving the predictive value of interventional animal models data
Zeiss CJ. Improving the predictive value of interventional animal models data. Drug Discovery Today 2014, 20: 475-482. PMID: 25448761, PMCID: PMC4417064, DOI: 10.1016/j.drudis.2014.10.015.Peer-Reviewed Original ResearchConceptsAnimal studiesSignificant potential confoundersAnimal model dataPercent of interventionsMore animal modelsPotential confoundersChronic diseasesImproved outcomesAmyloid hypothesisAnimal modelsPredictive valueAlzheimer's diseasePositive outcomesDiseaseTranslational successOutcomesPositive-outcome biasInterventionAdditional mechanismAnimalsMemantineConfoundersDonepezil