2009
CREB1/ATF1 Activation in Photoreceptor Degeneration and Protection
Beltran WA, Allore HG, Johnson E, Towle V, Tao W, Acland GM, Aguirre GD, Zeiss CJ. CREB1/ATF1 Activation in Photoreceptor Degeneration and Protection. Investigative Ophthalmology & Visual Science 2009, 50: 5355-5363. PMID: 19643965, PMCID: PMC3172238, DOI: 10.1167/iovs.09-3741.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 1AgedAged, 80 and overAnimalsArrestinCell CountCiliary Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDog DiseasesDogsFemaleGenotypeHumansImmunoblottingImmunoenzyme TechniquesMacular DegenerationMalePhosphorylationPhotoreceptor Cells, VertebrateRetinitis PigmentosaRhodopsinConceptsAge-related macular degenerationCiliary neurotrophic factorNormal canine retinaRcd1 dogsCanine retinaHuman retinaInnate protective responseNeuroprotective stimulusInner retinaNeurotrophic factorTranscription factor 1Macular degenerationRetinal protectionPhotoreceptor protectionP-CREB1Photoreceptor diseaseNormal dogsCanine modelPhotoreceptor degenerationRetinal degenerationProtective responseStrong immunolabelingCone photoreceptorsPhotoreceptor nucleiRetina
2005
CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina
Zeiss CJ, Allore HG, Towle V, Tao W. CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina. Experimental Eye Research 2005, 82: 395-404. PMID: 16143329, DOI: 10.1016/j.exer.2005.07.014.Peer-Reviewed Original ResearchConceptsCiliary neurotrophic factorInner retinal thicknessRetinitis pigmentosaRetinal thicknessGanglion cellsEffects of CNTFInner nuclear layer thicknessNormal retinal electrophysiologyGanglion cell morphologyOuter nuclear layerWild-type retinasDose-dependent mannerDose-dependent alterationsContralateral eyeControl dogsNeurotrophic factorExpression of rhodopsinRetinal electrophysiologyNuclear layerProtective effectRetinal morphologyEntire retinaAnimal modelsCone arrestinCanine model