2017
Safety and Efficacy of AAV5 Vectors Expressing Human or Canine CNGB3 in CNGB3-Mutant Dogs
Ye GJ, Komáromy AM, Zeiss C, Calcedo R, Harman CD, Koehl KL, Stewart GA, Iwabe S, Chiodo VA, Hauswirth WW, Aguirre GD, Chulay JD. Safety and Efficacy of AAV5 Vectors Expressing Human or Canine CNGB3 in CNGB3-Mutant Dogs. Human Gene Therapy 2017, 28: 197-207. PMID: 29020838, PMCID: PMC5733651, DOI: 10.1089/humc.2017.125.Peer-Reviewed Original ResearchConceptsHuman CNGB3Immune responseHigh dosesT cell immune responsesHigh-dose groupLow-dose groupInherited retinal disorderImmune-mediated toxicitiesHigher vector doseCone photoreceptor functionDifferent dose levelsFocal chorioretinitisRetinal toxicityVisual acuityInflammatory responseAAV vectorsRetinal disordersSubretinal injectionCone functionDose levelsCone photoreceptorsPhotoreceptor functionCNGB3AAV5 vectorVector dose
2005
CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina
Zeiss CJ, Allore HG, Towle V, Tao W. CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina. Experimental Eye Research 2005, 82: 395-404. PMID: 16143329, DOI: 10.1016/j.exer.2005.07.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArrestinCiliary Neurotrophic FactorDogsDose-Response Relationship, DrugImmunohistochemistryModels, AnimalRecoverinRetinaRetinal Cone Photoreceptor CellsRetinal DegenerationRetinal Ganglion CellsRhodopsinConceptsCiliary neurotrophic factorInner retinal thicknessRetinitis pigmentosaRetinal thicknessGanglion cellsEffects of CNTFInner nuclear layer thicknessNormal retinal electrophysiologyGanglion cell morphologyOuter nuclear layerWild-type retinasDose-dependent mannerDose-dependent alterationsContralateral eyeControl dogsNeurotrophic factorExpression of rhodopsinRetinal electrophysiologyNuclear layerProtective effectRetinal morphologyEntire retinaAnimal modelsCone arrestinCanine model