2017
From Reproducibility to Translation in Neurodegenerative Disease.
Zeiss CJ. From Reproducibility to Translation in Neurodegenerative Disease. ILAR Journal 2017, 58: 106-114. PMID: 28444192, DOI: 10.1093/ilar/ilx006.Peer-Reviewed Original ResearchConceptsNeurodegenerative diseasesPreclinical studiesDisease-altering treatmentsComplex human neurodegenerative diseasesBody of evidenceAnimal study designHuman neurodegenerative diseasesOutcome measuresTherapeutic studiesPreclinical successPharmacologic criteriaTherapeutic potentialStudy designDiseaseIndividual diseasesAnimal experimentsBiomarker dataTranslational purposesCell-based systemsConcept studyStudy design methodsPredictive validityPhenotypic variabilityPatientsStudy
2013
Translational models of ocular disease
Zeiss CJ. Translational models of ocular disease. Veterinary Ophthalmology 2013, 16: 15-33. PMID: 23750503, DOI: 10.1111/vop.12065.Peer-Reviewed Original ResearchConceptsLarge animal modelIntraocular neoplasiaStromal diseaseOcular diseasesAnimal modelsRetinal dystrophyTherapeutic potentialTranslational modelClinical veterinary medicineLaboratory animalsDomestic animalsDiseaseHuman medicineAnimalsVeterinary medicineMechanistic discoveriesGenetic contributionHumansMedicineUveitis