Medial amygdalar tau is associated with mood symptoms in preclinical Alzheimer’s disease
Li J, Tun S, Ficek-Tani B, Xu W, Wang S, Horien C, Toyonaga T, Nuli S, Zeiss C, Powers A, Zhao Y, Mormino E, Fredericks C. Medial amygdalar tau is associated with mood symptoms in preclinical Alzheimer’s disease. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39059466, DOI: 10.1016/j.bpsc.2024.07.012.Peer-Reviewed Original ResearchAssociated with mood symptomsMood symptomsAmyloid-positive individualsMedial amygdalaSeed-based functional connectivity analysisAssociated with anxiety symptomsSelf-reported mood symptomsPost hoc correlation analysisAlzheimer's diseaseFunctional connectivity analysisPreclinical Alzheimer's diseaseTau bindingOrbitofrontal cortexTau depositionAmygdalar connectivityEmotional processingAnxiety symptomsRetrosplenial cortexBetween-group differencesAmygdalaFunctional connectivityLateral amygdalaConnectivity analysisDepression scoresNeuropsychiatric symptoms