Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis
Goldstein J, Roth E, Roberts N, Zwick R, Lin S, Fletcher S, Tadeu A, Wu C, Beck A, Zeiss C, Suárez-Fariñas M, Horsley V. Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis. Molecular Biology Of The Cell 2015, 26: 3606-3614. PMID: 26310443, PMCID: PMC4603931, DOI: 10.1091/mbc.e15-05-0282.Peer-Reviewed Original ResearchConceptsDMBA/TPA-induced skin tumorigenesisFollicular stem cellsSkin tumorigenesisDMBA metabolismDMBA-induced DNA damageSquamous cell carcinoma formationSkin squamous cell carcinomaStem cellsSquamous cell carcinomaEndogenous expressionRate of tumorigenesisImmunosuppressive therapyCalcineurin inhibitorsCell carcinomaSkin tumorsHigh incidenceCarcinoma formationHair follicle bulge stem cellsMiceNFATc1Tumor initiationActive NFATc1Suppress tumorigenesisBulge stem cellsInducible deletion