2019
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Rattray NJW, Trivedi DK, Xu Y, Chandola T, Johnson CH, Marshall AD, Mekli K, Rattray Z, Tampubolon G, Vanhoutte B, White IR, Wu FCW, Pendleton N, Nazroo J, Goodacre R. Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty. Nature Communications 2019, 10: 5027. PMID: 31690722, PMCID: PMC6831565, DOI: 10.1038/s41467-019-12716-2.Peer-Reviewed Original ResearchConceptsRisk of frailtySocial care costsSubstantial economic burdenAnalysis of serumFrailty indexGas chromatography-mass spectrometry metabolomicsMetabolic dysregulationEconomic burdenVitamin ECare costsPoor healthPopulation-level assessmentFrailtyOlder peopleLongitudinal validationMetabolic phenotypeGlobal AGEingLater lifeMultivariate regressionSignificant metabolitesCarnitine shuttleDysregulationGreater proportionHealthPhenotype
2018
Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy
Warth B, Raffeiner P, Granados A, Huan T, Fang M, Forsberg EM, Benton HP, Goetz L, Johnson CH, Siuzdak G. Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy. Cell Chemical Biology 2018, 25: 291-300.e3. PMID: 29337187, PMCID: PMC5856613, DOI: 10.1016/j.chembiol.2017.12.010.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCarbonDietFemaleGenisteinHumansLetrozoleMCF-7 CellsMetabolomeMetabolomicsPhytoestrogensPiperazinesPrincipal Component AnalysisPyridinesReceptors, EstrogenZearalenoneConceptsEffects of palbociclibPositive breast cancerUS FDA approvalGlobal metabolomics approachMCF-7 cellsCombination therapyBreast cancerEstrogen receptorMetabolic effectsPhytoestrogen genisteinFDA approvalModel xenoestrogenCellular metabolismCancer therapyFunctional assaysXenoestrogensPathway modificationTherapyMetabolomics approachCombination cancer therapyFatty acidsEstrogenic mycotoxin zearalenoneProliferation experimentsMetabolitesMetabolism