2019
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Rattray NJW, Trivedi DK, Xu Y, Chandola T, Johnson CH, Marshall AD, Mekli K, Rattray Z, Tampubolon G, Vanhoutte B, White IR, Wu FCW, Pendleton N, Nazroo J, Goodacre R. Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty. Nature Communications 2019, 10: 5027. PMID: 31690722, PMCID: PMC6831565, DOI: 10.1038/s41467-019-12716-2.Peer-Reviewed Original ResearchConceptsRisk of frailtySocial care costsSubstantial economic burdenAnalysis of serumFrailty indexGas chromatography-mass spectrometry metabolomicsMetabolic dysregulationEconomic burdenVitamin ECare costsPoor healthPopulation-level assessmentFrailtyOlder peopleLongitudinal validationMetabolic phenotypeGlobal AGEingLater lifeMultivariate regressionSignificant metabolitesCarnitine shuttleDysregulationGreater proportionHealthPhenotype
2018
Beyond genomics: understanding exposotypes through metabolomics
Rattray NJW, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JPA, Johnson CH. Beyond genomics: understanding exposotypes through metabolomics. Human Genomics 2018, 12: 4. PMID: 29373992, PMCID: PMC5787293, DOI: 10.1186/s40246-018-0134-x.Peer-Reviewed Original ResearchConceptsGene-environment interactionsChallenges of metabolomicsIntegration of genomicsHuman genomeMultiple genetic variantsGenetic variationGenomic technologiesAssociation studiesMetabolic traitsMetabolite productionMetabolic processesIndividual phenotypesMetabolome-wide association studyProtein synthesisHuman population levelGenetic variantsBiological impactGenomicsDisease mechanismsMetabolomic informationWealth of informationPopulation levelSmall moleculesMetabolomicsTraits