Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches
Vollmar A, Rattray NJW, Cai Y, Santos-Neto ÁJ, Deziel NC, Jukic AMZ, Johnson CH. Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches. Metabolites 2019, 9: 198. PMID: 31546636, PMCID: PMC6835889, DOI: 10.3390/metabo9100198.Peer-Reviewed Original ResearchUrinary metabolomics dataKidney functionOrthogonal partial least squares discriminant analysisUntargeted mass spectrometry-based metabolomics analysisCreatinine adjustmentUrine samplesMetabolomic analysisEarly-life exposomeMass spectrometry-based metabolomics analysisTime of conceptionSpecific gravity adjustmentCritical developmental windowMaternal urineEarly pregnancyPericonceptional periodUrinary concentrationsPost-implantation samplesUrinary dilutionUntargeted metabolomics analysisUrine concentrationsUnsupervised principal component analysisStudy objectiveDevelopmental windowMetabolomics dataMetabolomics studies