Activation Induced Cytidine Deaminase-Associated DNA Repair Pathways Influence Germinal Center B Cell Lymphomagenesis
Gu X, Booth C, Liu Z, Strout M. Activation Induced Cytidine Deaminase-Associated DNA Repair Pathways Influence Germinal Center B Cell Lymphomagenesis. Blood 2013, 122: 1247. DOI: 10.1182/blood.v122.21.1247.1247.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaB-cell lymphomaMsh2-/- miceCell lymphomaB cellsChromosome abnormalitiesLarge B-cell lymphomaShorter median timePre-B-cell tumorsSquamous cell carcinomaFollicular B-cell lymphomaT-cell lymphomaHuman diffuse large B-cell lymphomaGerminal center B cellsMSH2-dependent mismatch repairPathogenesis of GCSingle-deficient miceDevelopment of DLBCLNet protective effectDevelopment of tumorsClonal mutationsPre-B cell lymphomaGC B cellsMedian survivalMedian time