2024
Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design
Gross R, Thaweethai T, Rosenzweig E, Chan J, Chibnik L, Cicek M, Elliott A, Flaherman V, Foulkes A, Witvliet M, Gallagher R, Gennaro M, Jernigan T, Karlson E, Katz S, Kinser P, Kleinman L, Lamendola-Essel M, Milner J, Mohandas S, Mudumbi P, Newburger J, Rhee K, Salisbury A, Snowden J, Stein C, Stockwell M, Tantisira K, Thomason M, Truong D, Warburton D, Wood J, Ahmed S, Akerlundh A, Alshawabkeh A, Anderson B, Aschner J, Atz A, Aupperle R, Baker F, Balaraman V, Banerjee D, Barch D, Baskin-Sommers A, Bhuiyan, Bind M, Bogie A, Bradford T, Buchbinder N, Bueler E, Bükülmez H, Casey B, Chang L, Chrisant M, Clark D, Clifton R, Clouser K, Cottrell L, Cowan K, D’Sa V, Dapretto M, Dasgupta S, Dehority W, Dionne A, Dummer K, Elias M, Esquenazi-Karonika S, Evans D, Faustino E, Fiks A, Forsha D, Foxe J, Friedman N, Fry G, Gaur S, Gee D, Gray K, Handler S, Harahsheh A, Hasbani K, Heath A, Hebson C, Heitzeg M, Hester C, Hill S, Hobart-Porter L, Hong T, Horowitz C, Hsia D, Huentelman M, Hummel K, Irby K, Jacobus J, Jacoby V, Jone P, Kaelber D, Kasmarcak T, Kluko M, Kosut J, Laird A, Landeo-Gutierrez J, Lang S, Larson C, Lim P, Lisdahl K, McCrindle B, McCulloh R, McHugh K, Mendelsohn A, Metz T, Miller J, Mitchell E, Morgan L, Müller-Oehring E, Nahin E, Neale M, Ness-Cochinwala M, Nolan S, Oliveira C, Osakwe O, Oster M, Payne R, Portman M, Raissy H, Randall I, Rao S, Reeder H, Rosas J, Russell M, Sabati A, Sanil Y, Sato A, Schechter M, Selvarangan R, Tejtel S, Shakti D, Sharma K, Squeglia L, Srivastava S, Stevenson M, Szmuszkovicz J, Talavera-Barber M, Teufel R, Thacker D, Trachtenberg F, Udosen M, Warner M, Watson S, Werzberger A, Weyer J, Wood M, Yin H, Zempsky W, Zimmerman E, Dreyer B, Consortium O. Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design. PLOS ONE 2024, 19: e0285635. PMID: 38713673, PMCID: PMC11075869, DOI: 10.1371/journal.pone.0285635.Peer-Reviewed Original ResearchConceptsYoung adultsClinical courseAdolescent Brain Cognitive DevelopmentCaregiver-child pairsLong-term outcomesObservational cohort studyOutcomes of COVID-19De novo cohortAdolescent Brain Cognitive Development StudySociodemographic correlatesCommunity partnersBaseline assessmentLongitudinal follow-upPotential therapeutic interventionsPediatric protocolsCohort studyCollaborative partnershipsProspective cohortFollow-upStudy protocolFederal partnersNIH Researching COVIDLong-term outcomes of COVID-19Enhanced recoveryData collectionGuidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce
Willis Z, Oliveira C, Abzug M, Anosike B, Ardura M, Bio L, Boguniewicz J, Chiotos K, Downes K, Grapentine S, Hersh A, Heston S, Hijano D, Huskins W, James S, Jones S, Lockowitz C, Lloyd E, MacBrayne C, Maron G, McDonough M, Miller C, Morton T, Olivero R, Orscheln R, Schwenk H, Singh P, Soma V, Sue P, Vora S, Nakamura M, Wolf J. Guidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce. Journal Of The Pediatric Infectious Diseases Society 2024, 13: 159-185. PMID: 38339996, DOI: 10.1093/jpids/piad116.Peer-Reviewed Original ResearchConceptsRisk factorsRisk stratificationPediatric intensive care medicineEffects of therapyNon-hospitalized childrenPediatric infectious diseasesSevere COVID-19Cases of infectionMeta-analysis of dataIntensive care medicineClinical characteristicsPreventive therapyPediatric populationManagement of COVID-19Fatal infectionConsensus statementSevere illnessTherapyMeta-analysisTherapeutic interventionsSARS-CoV-2Expert consensusCare medicineRe-convenedGuidance statements
2023
Monoclonal Antibody Use for Coronavirus Disease 2019 in Pediatric Patients: A Multicenter Retrospective Study
Sherman G, Lamb G, Sharma T, Lloyd E, Nagel J, Dandam N, Oliveira C, Sheikha H, Anosike B, Lee P, Vora S, Patel K, Sue P, Rubbab B, Yarbrough A, Ganapathi L, Nakamura M. Monoclonal Antibody Use for Coronavirus Disease 2019 in Pediatric Patients: A Multicenter Retrospective Study. Journal Of The Pediatric Infectious Diseases Society 2023, 12: 152-155. PMID: 36928172, PMCID: PMC10112679, DOI: 10.1093/jpids/piac124.Peer-Reviewed Original ResearchRoutine saliva testing for SARS-CoV-2 in children: Methods for partnering with community childcare centers
Rayack E, Askari H, Zirinsky E, Lapidus S, Sheikha H, Peno C, Kazemi Y, Yolda-Carr D, Liu C, Grubaugh N, Ko A, Wyllie A, Spatz E, Oliveira C, Bei A. Routine saliva testing for SARS-CoV-2 in children: Methods for partnering with community childcare centers. Frontiers In Public Health 2023, 11: 1003158. PMID: 36817891, PMCID: PMC9936085, DOI: 10.3389/fpubh.2023.1003158.Peer-Reviewed Original ResearchConceptsParents/guardiansOnline patient portalYounger age groupsSARS-CoV-2Age groupsSurveillance programSaliva collectionSARS-CoV-2 testingSARS-CoV-2 screeningWeekly saliva samplesRT-PCR testingChildcare centre staffCritical age groupRoutine surveillance toolRoutine testing programsChildcare centersCOVID-19 transmissionAsymptomatic screeningSaliva collection methodNasal swabsPatient portalsSymptomatic testingPublic health dataSaliva samplesChildcare facilitiesClinical Epidemiology of Pediatric Coronavirus Disease 2019 and its Postacute Sequelae
Habet V, Oliveira C. Clinical Epidemiology of Pediatric Coronavirus Disease 2019 and its Postacute Sequelae. Seminars In Respiratory And Critical Care Medicine 2023, 44: 066-074. PMID: 36646086, PMCID: PMC9926930, DOI: 10.1055/s-0042-1759566.Commentaries, Editorials and LettersConceptsClinical epidemiologyCOVID-19Pediatric coronavirus disease 2019Pediatric COVID-19Multisystem inflammatory syndromeAcute respiratory illnessCoronavirus disease 2019 (COVID-19) pandemicCoronavirus disease 2019Disease 2019 pandemicQuality of lifeHealth care systemBenign illnessCardiogenic shockInflammatory syndromeLong COVIDPostinfectious sequelaePediatric deathsRespiratory illnessPostacute sequelaeDisease 2019Mortality rateConsiderable burdenAge groupsCare systemSequelae
2022
Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data
Fashina T, Miller C, Paintsil E, Niccolai L, Brandt C, Oliveira C. Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data. Journal Of The Pediatric Infectious Diseases Society 2022, 12: 113-116. PMID: 36548966, PMCID: PMC9969330, DOI: 10.1093/jpids/piac132.Peer-Reviewed Original ResearchPediatric COVID-19 Health Disparities and Vaccine Equity
Oliveira CR, Feemster KA, Ulloa ER. Pediatric COVID-19 Health Disparities and Vaccine Equity. Journal Of The Pediatric Infectious Diseases Society 2022, 11: s141-s147. PMID: 36124679, PMCID: PMC9494479, DOI: 10.1093/jpids/piac091.Commentaries, Editorials and LettersConceptsVaccine equityHealth disparitiesLong-term complicationsCOVID-19 health disparitiesCOVID-19 infectionCOVID-19 vaccineMild illnessPediatric populationVaccine uptakePoor outcomeSevere diseaseVaccine inequityMost childrenEthnic minority groupsChildrenSame childrenInfectionLow-income homesDisparitiesComplicationsGroupVaccineIllnessDiseaseSeverityUpdated Guidance on Use and Prioritization of Monoclonal Antibody Therapy for Treatment of COVID-19 in Adolescents
Wolf J, Abzug MJ, Anosike BI, Vora SB, Waghmare A, Sue PK, Olivero RM, Oliveira CR, James SH, Morton TH, Maron GM, Young JL, Orscheln RC, Schwenk HT, Bio LL, Willis ZI, Lloyd EC, Hersh AL, Huskins CW, Soma VL, Ratner AJ, Hayes M, Downes K, Chiotos K, Grapentine SP, Wattier RL, Lamb GS, Zachariah P, Nakamura MM. Updated Guidance on Use and Prioritization of Monoclonal Antibody Therapy for Treatment of COVID-19 in Adolescents. Journal Of The Pediatric Infectious Diseases Society 2022, 11: 177-185. PMID: 35107571, PMCID: PMC8903349, DOI: 10.1093/jpids/piab124.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMonoclonal antibody therapyPediatric infectious diseasesAntibody therapyEmergency use authorizationSevere diseasePostexposure prophylaxisHigh riskCOVID-19Severe acute respiratory syndrome coronavirus 2Certain high-risk conditionsSpecific monoclonal antibody therapyAcute respiratory syndrome coronavirus 2Infectious diseasesRespiratory syndrome coronavirus 2Moderate COVID-19Pediatric critical care medicineSyndrome coronavirus 2Coronavirus disease 2019Critical care medicineHigh-risk conditionsSeries of teleconferencesHigh-risk exposureBamlanivimab monotherapyInfusion reactionsControlled Trials
2021
The clinical epidemiology of coronavirus disease 2019 in children and adolescents mirrors the widening gap in healthcare disparities
Zirinsky E, Paintsil E, Oliveira CR. The clinical epidemiology of coronavirus disease 2019 in children and adolescents mirrors the widening gap in healthcare disparities. Current Opinion In Pediatrics 2021, 33: 281-285. PMID: 33871422, PMCID: PMC8635086, DOI: 10.1097/mop.0000000000001018.Commentaries, Editorials and LettersConceptsClinical epidemiologyRespiratory diseaseSARS-CoV-2-related deathAcute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemicSevere lower respiratory diseaseHealth disparitiesSARS-CoV-2 infectionLongstanding health disparitiesKawasaki-like syndromeLower respiratory diseaseCoronavirus 2 pandemicCoronavirus disease 2019Upper respiratory diseaseSARS-CoV-2Ethnic health disparitiesPandemics/epidemicsCardiovascular shockInfluenza seasonDisease 2019Healthcare disparitiesUS populationEthnic disparitiesHispanic childrenMore childrenInitial Guidance on Use of Monoclonal Antibody Therapy for Treatment of Coronavirus Disease 2019 in Children and Adolescents
Wolf J, Abzug MJ, Wattier RL, Sue PK, Vora SB, Zachariah P, Dulek DE, Waghmare A, Olivero R, Downes KJ, James SH, Pinninti SG, Yarbrough A, Aldrich ML, MacBrayne CE, Soma VL, Grapentine SP, Oliveira CR, Hayes M, Kimberlin DW, Jones SB, Bio LL, Morton TH, Hankins JS, Marόn-Alfaro G, Timberlake K, Young JL, Orscheln RC, Schwenk HT, Goldman DL, Groves HE, Huskins WC, Rajapakse NS, Lamb GS, Tribble AC, Lloyd E, Hersh AL, Thorell EA, Ratner AJ, Chiotos K, Nakamura MM. Initial Guidance on Use of Monoclonal Antibody Therapy for Treatment of Coronavirus Disease 2019 in Children and Adolescents. Journal Of The Pediatric Infectious Diseases Society 2021, 10: 629-634. PMID: 33388760, PMCID: PMC7799019, DOI: 10.1093/jpids/piaa175.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMonoclonal antibody therapyHigh-risk groupAntibody therapyEmergency use authorizationCOVID-19Moderate coronavirus disease 2019Pediatric intensive care medicinePediatric-specific evidenceTreatment of mildPediatric infectious diseasesHigh-quality evidenceCoronavirus disease 2019Intensive care medicineSeries of teleconferencesREGN-COV2Infusion reactionsPediatric HematologyTimely administrationRisk factorsRoutine administrationDisease 2019Severe diseaseCare medicineHigh riskModest benefit
2020
Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Children in a Large Regional US Health System During the Coronavirus Disease 2019 Pandemic.
Peaper DR, Murdzek C, Oliveira CR, Murray TS. Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Children in a Large Regional US Health System During the Coronavirus Disease 2019 Pandemic. The Pediatric Infectious Disease Journal 2020, 40: 175-181. PMID: 33399431, PMCID: PMC8852689, DOI: 10.1097/inf.0000000000003024.Peer-Reviewed Original ResearchConceptsYale New Haven Health SystemSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Subset of childrenPediatric casesHealth systemCycle threshold valuesCoronavirus 2Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNACross-sectional time-series studyCoronavirus disease 2019 (COVID-19) testingPositive pediatric casesSimilar cycle threshold valuesCoronavirus disease 2019 (COVID-19) pandemicUpper respiratory tractCoronavirus disease 2019Large health systemYears of ageDisease 2019 pandemicUS health systemAmbulatory locationsVirology resultsAsymptomatic childrenSevere Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth
Fernandes DM, Oliveira CR, Guerguis S, Eisenberg R, Choi J, Kim M, Abdelhemid A, Agha R, Agarwal S, Aschner JL, Avner JR, Ballance C, Bock J, Bhavsar SM, Campbell M, Clouser KN, Gesner M, Goldman DL, Hammerschlag MR, Hymes S, Howard A, Jung HJ, Kohlhoff S, Kojaoghlanian T, Lewis R, Nachman S, Naganathan S, Paintsil E, Pall H, Sy S, Wadowski S, Zirinsky E, Cabana MD, Herold BC, Consortium T. Severe Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth. The Journal Of Pediatrics 2020, 230: 23-31.e10. PMID: 33197493, PMCID: PMC7666535, DOI: 10.1016/j.jpeds.2020.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBiomarkersChildChild, PreschoolConnecticutCOVID-19C-Reactive ProteinFemaleHospitalizationHumansHypoxiaInfantIntensive Care UnitsLymphocyte CountMaleMultivariate AnalysisNew JerseyNew YorkPediatric ObesityProcalcitoninProspective StudiesRetrospective StudiesSeverity of Illness IndexSystemic Inflammatory Response SyndromeTroponinYoung AdultConceptsSARS-CoV-2 infectionRespiratory diseaseDisease severityClinical featuresAcute SARS-CoV-2 infectionGreater C-reactive proteinLow absolute lymphocyte countFuture prognostic toolAbsolute lymphocyte countTime of hospitalizationC-reactive proteinIntensive care unitSevere respiratory diseaseNon-Hispanic blacksRace/ethnicitySevere MISInflammatory syndromeLymphocyte countHospital admissionPediatric patientsCare unitMultivariable analysisProspective studyHospitalized childrenClinical managementMulticenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2
Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Oliveira CR, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich ML, Goldman DL, Groves HE, Rajapakse NS, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, Nakamura MM. Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2. Journal Of The Pediatric Infectious Diseases Society 2020, 10: 34-48. PMID: 32918548, PMCID: PMC7543452, DOI: 10.1093/jpids/piaa115.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMechanical ventilationCOVID-19Pediatric infectious disease physiciansInvasive mechanical ventilationSupplemental oxygen requirementInfectious disease physiciansUse of hydroxychloroquineUse of remdesivirNoninvasive mechanical ventilationUse of antiviralsCoronavirus disease 2019Series of teleconferencesPotential antiviral activityLopinavir-ritonavirCritical illnessDisease physiciansMost patientsSupportive careMembrane oxygenationPediatric patientsAntiviral therapyMild courseSevere illnessIll childrenClinical trials
2018
Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic
Deshmukh U, Oliveira CR, Griggs S, Coleman E, Avni-Singer L, Pathy S, Shapiro ED, Sheth SS. Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic. Vaccine 2018, 36: 3599-3605. PMID: 29759380, PMCID: PMC6314176, DOI: 10.1016/j.vaccine.2018.05.039.Peer-Reviewed Original ResearchConceptsIntervention bundleOB/GYN clinicPrevalence of womenUninsured womenVaccine uptakeAttributable reductionsMissed opportunityHPV vaccine seriesVaccine-eligible visitsVaccine-eligible womenHPV vaccine uptakeMonthly rateYoung adult womenLast study monthInterrupted time series modelHPV vaccineVaccine seriesMedical recordsHispanic womenAdult womenWhite womenStudy periodYoung adultsVaccineWomen
2016
Influenza-like illness in an urban community of Salvador, Brazil: incidence, seasonality and risk factors
Oliveira CR, Costa GSR, Paploski IAD, Kikuti M, Kasper AM, Silva MMO, Tavares AS, Cruz JS, Queiroz TL, Lima HCAV, Calcagno J, Reis MG, Weinberger DM, Shapiro ED, Ko AI, Ribeiro GS. Influenza-like illness in an urban community of Salvador, Brazil: incidence, seasonality and risk factors. BMC Infectious Diseases 2016, 16: 125. PMID: 26975185, PMCID: PMC4791800, DOI: 10.1186/s12879-016-1456-8.Peer-Reviewed Original ResearchConceptsInfluenza-like illnessYears of ageAcute febrile illnessAnnual incidenceRisk of ILIChildren 5Year oldsIncidence of ILIMean annual incidenceEpidemiology of influenzaCommunity-based surveillanceNegative test resultsSeasonal influenza transmissionILI peakMethodsBetween 2009Febrile illnessSore throatRegression modelsDisease burdenRisk factorsSchool-aged childrenEmergency unitInfluenza transmissionSignificant burdenYoung school-age children
2015
Update on persistent symptoms associated with Lyme disease
Oliveira CR, Shapiro ED. Update on persistent symptoms associated with Lyme disease. Current Opinion In Pediatrics 2015, 27: 100-104. PMID: 25490690, PMCID: PMC4417349, DOI: 10.1097/mop.0000000000000167.Commentaries, Editorials and LettersConceptsViable B. burgdorferiLyme diseasePersistent symptomsB. burgdorferiConventional treatmentAntimicrobial treatmentCommon vector-borne illnessPersistent active infectionPersistent nonspecific symptomsVector-borne illnessConventional antimicrobial treatmentPersistent arthritisChronic symptomsNonspecific symptomsOngoing symptomsErythema migransActive infectionPersistent infectionRecent studiesSlow clearancePatientsSymptomsDiseaseNonviable organismsInfection
2014
Brain Magnetic Resonance Imaging of Infants with Bacterial Meningitis
Oliveira CR, Morriss MC, Mistrot JG, Cantey JB, Doern CD, Sánchez PJ. Brain Magnetic Resonance Imaging of Infants with Bacterial Meningitis. The Journal Of Pediatrics 2014, 165: 134-139. PMID: 24726712, PMCID: PMC6855593, DOI: 10.1016/j.jpeds.2014.02.061.Peer-Reviewed Original ResearchConceptsBrain magnetic resonance imagingMagnetic resonance imagingBacterial meningitisPositive bacterial culturesCerebrospinal fluidClinical managementNeurosurgical interventionMedical CenterNormal brain magnetic resonance imagingCulture-confirmed bacterial meningitisPositive CSF culture resultsResonance imagingAbnormal magnetic resonance imagingMultiple logistic regression analysisAbnormal neurologic examinationCSF culture resultsChildren's Medical CenterLogistic regression analysisMonths of ageLate seizuresCerebral infarctsLeptomeningeal enhancementAntibiotic therapyCSF cultureNeurologic examination