Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis
Price NL, Rotllan N, Canfrán-Duque A, Zhang X, Pati P, Arias N, Moen J, Mayr M, Ford DA, Baldán Á, Suárez Y, Fernández-Hernando C. Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis. Cell Reports 2017, 21: 1317-1330. PMID: 29091769, PMCID: PMC5687841, DOI: 10.1016/j.celrep.2017.10.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAtherosclerosisATP Binding Cassette Transporter 1Blood GlucoseCells, CulturedCholesterolCholesterol, HDLDisease ProgressionGene Regulatory NetworksMacrophages, PeritonealMaleMiceMice, Inbred C57BLMice, KnockoutMicroRNAsMitochondrial Trifunctional Protein, beta SubunitMyocardiumReceptors, LDLConceptsPlaque burdenMiR-33MiR-33-deficient miceReduced plaque burdenProgression of atherosclerosisPro-atherogenic effectsMacrophage cholesterol effluxDecreases lipid accumulationTreatment of atherosclerosisMacrophage-specific lossMiR-33 deficiencyPromotes obesityHDL levelsInsulin resistancePlaque macrophagesProtective effectHyperlipidemic conditionsCholesterol effluxPlaque developmentLipid metabolismAtherosclerosisLipid accumulationHDL biogenesisPromising targetMacrophagesNoncoding RNAs in Cholesterol Metabolism and Atherosclerosis
Price N, Fernández-Hernando C. Noncoding RNAs in Cholesterol Metabolism and Atherosclerosis. Cardiac And Vascular Biology 2017, 2: 21-37. DOI: 10.1007/978-3-319-52945-5_2.Peer-Reviewed Original ResearchLow-density lipoprotein cholesterolPlasma LDL-C levelsDysregulation of cholesterolLDL-C levelsPrimary risk factorTreatment of atherosclerosisLipoprotein cholesterolCardiometabolic diseasesCholesterol levelsRisk factorsEffective therapyCholesterol metabolismAtherosclerosisHuman morbidityProper metabolic functionProminent causeElevated levelsLipid homeostasisGenetic factorsDiseaseCholesterolMetabolic functionsMorbidityLevelsPosttranscriptional level