2021
PCSK9 Activity Is Potentiated Through HDL Binding
Burnap SA, Sattler K, Pechlaner R, Duregotti E, Lu R, Theofilatos K, Takov K, Heusch G, Tsimikas S, Fernández-Hernando C, Berry SE, Hall WL, Notdurfter M, Rungger G, Paulweber B, Willeit J, Kiechl S, Levkau B, Mayr M. PCSK9 Activity Is Potentiated Through HDL Binding. Circulation Research 2021, 129: 1039-1053. PMID: 34601896, PMCID: PMC8579991, DOI: 10.1161/circresaha.121.319272.Peer-Reviewed Original ResearchConceptsProprotein convertase subtilisin/kexin type 9High-density lipoproteinSmall high-density lipoproteinHDL proteomeApolipoprotein C3Low-density lipoprotein receptor degradationPlasma proprotein convertase subtilisin/kexin type 9Convertase subtilisin/kexin type 9Subtilisin/kexin type 9Coronary artery diseaseLow-density lipoprotein uptakeArtery diseasePostprandial lipaemiaBruneck StudyPCSK9 levelsPostprandial responseTriglyceride levelsPlasma levelsApolipoprotein profilesSAPHIR studyIndependent cohortPhospholipid transfer proteinMagnetic resonancePCSK9 activityType 9
2012
MicroRNAs regulating lipid metabolism in atherogenesis
Rayner K, Fernandez-Hernando C, Moore K. MicroRNAs regulating lipid metabolism in atherogenesis. Thrombosis And Haemostasis 2012, 107: 642-647. PMID: 22274626, PMCID: PMC3618663, DOI: 10.1160/th11-10-0694.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisATP Binding Cassette Transporter 1ATP-Binding Cassette TransportersCholesterolDisease Models, AnimalFatty AcidsGene Expression RegulationHumansLipid MetabolismLipoproteins, HDLLipoproteins, VLDLLiverMiceMicroRNAsModels, BiologicalSterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding Protein 2TriglyceridesConceptsSmall non-coding RNAsImportant post-transcriptional regulatorsCellular sterol levelsPost-transcriptional regulatorsNon-coding RNAsVariety of genesSterol response elementFatty acid homeostasisIntronic microRNAsLipid metabolismFatty acid synthesisHost genesTranscription factorsProtein geneCholesterol exportMetabolic programsKey regulatorFatty acid oxidationResponse elementHigh-density lipoproteinMicroRNAsRelated metabolic diseasesGenesABCA1 pathwayAcid homeostasis