Curcumin promotes exosomes/microvesicles secretion that attenuates lysosomal cholesterol traffic impairment
Canfrán‐Duque A, Pastor Ó, Quintana‐Portillo R, Lerma M, de la Peña G, Martín‐Hidalgo A, Fernández‐Hernando C, Lasunción MA, Busto R. Curcumin promotes exosomes/microvesicles secretion that attenuates lysosomal cholesterol traffic impairment. Molecular Nutrition & Food Research 2013, 58: 687-697. PMID: 24288129, DOI: 10.1002/mnfr.201300350.Peer-Reviewed Original ResearchConceptsExosomes/microvesiclesMicrovesicle secretionEndosomes/lysosomesEndolysosomal originFlotillin-2Release of cholesterolTHP-1 differentiated macrophagesMultivesicular bodiesDifferent cell linesExosome markersSmall vesiclesTrafficking impairmentDifferentiated macrophagesTraffic impairmentCholesterol cell contentLysosomal storage diseaseCell linesEffect of curcuminCholesterol accumulationMicrovesiclesSecretion fluidVesiclesCellsCD63Cell content