A Gate Hinge Controls the Epithelial Calcium Channel TRPV5
van der Wijst J, Leunissen EH, Blanchard MG, Venselaar H, Verkaart S, Paulsen CE, Bindels RJ, Hoenderop JG. A Gate Hinge Controls the Epithelial Calcium Channel TRPV5. Scientific Reports 2017, 7: 45489. PMID: 28374795, PMCID: PMC5379628, DOI: 10.1038/srep45489.Peer-Reviewed Original ResearchConceptsEpithelial calcium channel TRPV5Detailed molecular insightStructure-function analysisSite-directed mutagenesisChannel gating mechanismCalcium channel TRPV5TRP channel familyCarboxy terminusDepth structure-function analysisFunctional crosstalkGlycine residueHomology modelingMolecular insightsChannel familyCell deathPermeation pathwayChannel functionChannel TRPV5Increased cell deathNovel insightsIntracellular poresGating mechanismFlexible linkerPore regionTRPV5