138 Redox Regulation of RAD51 and Homologous Recombination by Peroxiredoxin 1 and Electrophilic Nitro-fatty Acids
Skoko J, Asan A, Woodcock C, Cao J, Gaboriau D, Paulsen C, Attar M, Wingert B, Woodcock S, Schulte J, Ma H, Camacho C, Liu Y, Morrison C, Carroll K, Freeman B, Neumann C. 138 Redox Regulation of RAD51 and Homologous Recombination by Peroxiredoxin 1 and Electrophilic Nitro-fatty Acids. Free Radical Biology And Medicine 2017, 112: 100-101. DOI: 10.1016/j.freeradbiomed.2017.10.151.Peer-Reviewed Original ResearchOA-NO2Breast cancer cellsPeroxiredoxin 1Sensitization of cellsElectrophilic nitro-fatty acidsCancer cellsHuman breast cancer cellsNitro-fatty acidsPharmacological treatmentBreast cancerDNA damageRAD51 foci formationFoci formationCancerDNA double-strand breaksHomologous recombination repairPrimary targetSensitizationRepairCellsCellular responsesH2AX phosphorylationRecombination repairHomologous recombinationRedox regulation