Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells
Qiu C, Ma Y, Wang J, Peng S, Huang Y. Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. Nucleic Acids Research 2009, 38: 1240-1248. PMID: 19966271, PMCID: PMC2831306, DOI: 10.1093/nar/gkp1071.Peer-Reviewed Original ResearchConceptsRNA helicase APost-transcriptional regulationHuman embryonic stem cellsEmbryonic stem cellsLin28-dependent stimulationOct4 expressionPost-transcriptional regulatory factorsPluripotency factor OCT4Subset of mRNAsPost-transcriptional levelStem cellsTarget mRNA expressionMicroRNA processingFactors OCT4Observed regulationReporter systemRegulatory factorsEfficient translationLin28Novel mechanismMRNARegulationFirst evidenceExpressionMRNA expression