Clinical and Cytological Effects of Pimecrolimus Cream 1% after Resolution of Active Atopic Dermatitis Lesions by Topical Corticosteroids: A Randomized Controlled Trial
Bangert C, Strober B, Cork M, Ortonne J, Luger T, Bieber T, Ferguson A, Ecker R, Kopp T, Weise-Riccardi S, Guettner A, Stingl G. Clinical and Cytological Effects of Pimecrolimus Cream 1% after Resolution of Active Atopic Dermatitis Lesions by Topical Corticosteroids: A Randomized Controlled Trial. Dermatology 2010, 222: 36-48. PMID: 21150167, DOI: 10.1159/000321711.Peer-Reviewed Original ResearchConceptsPimecrolimus cream 1End of studyCream 1Vehicle creamTopical pimecrolimusAD lesionsAtopic dermatitisDouble-blind treatmentDermal dendritic cellsProportion of patientsAtopic dermatitis lesionsNumber of leukocytesAD remissionEczema AreaPlacebo creamSubclinical inflammationTopical corticosteroidsControlled TrialsDendritic cellsInflammatory infiltrateLangerhans cellsNonsignificant reductionSkin biopsiesT cellsOutcome measures