2019
Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence
Kavanaugh BC, Cancilliere MK, Fryc A, Tirrell E, Oliveira J, Oberman LM, Wexler BE, Carpenter LL, Spirito A. Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence. Child Neuropsychology 2019, 26: 754-769. PMID: 31876232, PMCID: PMC10629577, DOI: 10.1080/09297049.2019.1708295.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyChildChild, PreschoolDepressionExecutive FunctionFemaleHumansMaleNational Institute of Mental Health (U.S.)Neuropsychological TestsUnited StatesConceptsAnxiety/depressive symptomatologyGlobal deficit scoreDepressive symptomatologyDetection of impairmentHealth ToolboxDepressive symptom varianceNational InstituteChildhood/adolescenceSelf-reported depressionComparable psychometric propertiesSymptom varianceEF symptomsDeficit scoresDepression diagnosisDepressive symptomsClinical diagnosisChild-reported anxietyClinical neuropsychological measuresImpairmentMeasures of EFSymptomatologyDepressionNeuropsychological measuresSymptomsParent reportThe development of adaptive risk taking and the role of executive functions in a large sample of school-age boys and girls
Bell MD, Imal AE, Pittman B, Jin G, Wexler BE. The development of adaptive risk taking and the role of executive functions in a large sample of school-age boys and girls. Trends In Neuroscience And Education 2019, 17: 100120. PMID: 31685124, DOI: 10.1016/j.tine.2019.100120.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolCognitionDecision MakingExecutive FunctionFemaleHumansImpulsive BehaviorMaleNeuropsychological TestsRisk-TakingSchoolsSelf-ControlConceptsBalloon Analogue Risk TaskSchool-aged boysExecutive functionRisk TaskPartial mediatorAcademic achievementRisk takingBetter mathChild's schoolSchool characteristicsMiddle schoolLarge sampleTotal scoreSchoolsRecklessnessChildrenBoysBetter decisionsEmotionsGradeMeasuresFunctioningTaskProficiencyTaking
2016
Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression
Morimoto SS, Gunning FM, Wexler BE, Hu W, Ilieva I, Liu J, Nitis J, Alexopoulos GS. Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression. American Journal Of Geriatric Psychiatry 2016, 24: 816-820. PMID: 27591163, PMCID: PMC5873289, DOI: 10.1016/j.jagp.2016.06.010.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionCognitive remediation interventionsComputerized cognitive remediationPoor treatment responseFavorable treatment responseTreatment responseCognitive remediationRemediation interventionsMajor depressionNeuropsychological performanceElderly patientsOlder adultsLate-life depressionMontgomery-Asberg Depression Rating Scale scoreTreatment-resistant major depressionDepression Rating Scale scoresRating Scale scoresDepressionAntidepressant treatmentTreatment trialsScale scorePatientsBaselineGreater reductionDysfunction
2015
Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study
Kober H, Lacadie CM, Wexler BE, Malison RT, Sinha R, Potenza MN. Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study. Neuropsychopharmacology 2015, 41: 628-637. PMID: 26119472, PMCID: PMC5130138, DOI: 10.1038/npp.2015.193.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCD participantsCocaine dependenceCocaine cravingPG participantsPathological gamblingGender-specific therapiesBrain activityMagnetic resonance imagingNeural correlatesSelf-reported cravingInsula/Ventromedial prefrontal cortexNeurobiological similaritiesResonance imagingGambling urgesDrug cravingPrefrontal cortexDorsal mPFCControl participantsCravingFMRI studyMPFC regionFuture studiesParticipants
2014
Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits
Wexler BE, Ikezawa S, Corbera S. Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits. Schizophrenia Research 2014, 158: 163-169. PMID: 25096541, PMCID: PMC4240766, DOI: 10.1016/j.schres.2014.07.012.Peer-Reviewed Original ResearchConceptsHealthy controlsCognitive deficitsMs stimuliStructured Clinical InterviewDSM-IV criteriaModulation of responsesStimulus durationPictures of handsEvent Related PotentialsAdult outpatientsPain stimuliHealthy peoplePatientsClinical InterviewSchizoaffective disorderSchizophreniaMs stimulusSensory inputStimulus onsetSame durationDurationStimuliDeficitsResponseNeutral stimuli
2013
Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia
Colibazzi T, Wexler BE, Bansal R, Hao X, Liu J, Sanchez-Peña J, Corcoran C, Lieberman JA, Peterson BS. Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia. PLOS ONE 2013, 8: e55783. PMID: 23418459, PMCID: PMC3572102, DOI: 10.1371/journal.pone.0055783.Peer-Reviewed Original ResearchConceptsCortical thicknessWhite matterCortical surface areaGray matterAnatomical abnormalitiesGM volumeWM abnormalitiesContribution of abnormalitiesRegional GM volumeHealthy controlsHigh burdenCingulate gyrusTotal cortical surface areaThinner cortexSuperior frontalAbnormalitiesLocation of abnormalitiesPerisylvian cortexSchizophreniaWM surfaceBrainCortical surfaceBrain anatomyPatientsSerial position task
2012
Empathy in electrodermal responsive and nonresponsive patients with schizophrenia
Ikezawa S, Corbera S, Liu J, Wexler BE. Empathy in electrodermal responsive and nonresponsive patients with schizophrenia. Schizophrenia Research 2012, 142: 71-76. PMID: 23058162, PMCID: PMC3502678, DOI: 10.1016/j.schres.2012.09.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAntipsychotic AgentsChlorpromazineElectroencephalographyEmpathyEvoked PotentialsFemaleGalvanic Skin ResponseHumansMaleMiddle AgedNeuropsychological TestsPersonality TestsPsychiatric Status Rating ScalesPsychotic DisordersRecognition, PsychologySchizophreniaSchizophrenic PsychologySocial BehaviorConceptsSkin conductance responsesEvent Related PotentialsSocial cognitionEmotion-evoking stimuliHealthy controlsPictures of peopleAssessment of symptomsERP responsesPersonal distressConductance responsesRelated potentialsNonresponsive patientsSchizophrenia patientsSCR frequencyCognitionPatientsSocial functionSocial integrationPotential markerSchizophreniaDistressPainPrognosisSubgroupsSymptomsNeuroplasticity‐based computerized cognitive remediation for geriatric depression
Morimoto SS, Wexler BE, Alexopoulos GS. Neuroplasticity‐based computerized cognitive remediation for geriatric depression. International Journal Of Geriatric Psychiatry 2012, 27: 1239-1247. PMID: 22451346, PMCID: PMC3387346, DOI: 10.1002/gps.3776.Peer-Reviewed Original ResearchConceptsComputerized cognitive remediationCognitive remediationExecutive dysfunctionGeriatric depressionSpecific executive deficitsSpecific neurocognitive deficitsSpecific cerebral networksNovel treatment interventionsAvailable treatment studiesNovel treatment modelExecutive deficitsEmotional regulationNeurocognitive deficitsUnderlying neurobiologyMental health reportsCerebral networksOlder adultsTreatment modelTreatment interventionsDepressed eldersTreatment studiesBehavioral changesNew interventionsDepressionDeficitsComputerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study
Murthy NV, Mahncke H, Wexler BE, Maruff P, Inamdar A, Zucchetto M, Lund J, Shabbir S, Shergill S, Keshavan M, Kapur S, Laruelle M, Alexander R. Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study. Schizophrenia Research 2012, 139: 87-91. PMID: 22342330, DOI: 10.1016/j.schres.2012.01.042.Peer-Reviewed Original ResearchConceptsFunctional capacity outcome measuresCognitive Assessment InterviewBrain Fitness ProgramSignificant treatment effectOutcome measuresRegular antipsychotic medicationStable adult patientsNon-pharmacological methodsCognitive performanceTreatment effectsComputerized cognitive remediation trainingMultinational clinical trialsSingle-site studyTraining effectsCognitive remediation trainingOpen labelAdult patientsAntipsychotic medicationCAI scoreClinical trialsCognitive impairmentMulti-site studyExercise taskRemediation trainingNeuropsychological tasks
2011
Social Cognitive Impairments and Negative Symptoms in Schizophrenia: Are There Subtypes With Distinct Functional Correlates?
Bell MD, Corbera S, Johannesen JK, Fiszdon JM, Wexler BE. Social Cognitive Impairments and Negative Symptoms in Schizophrenia: Are There Subtypes With Distinct Functional Correlates? Schizophrenia Bulletin 2011, 39: 186-196. PMID: 21976710, PMCID: PMC3523908, DOI: 10.1093/schbul/sbr125.Peer-Reviewed Original ResearchConceptsHigher social cognitionLower social cognitionSocial cognitive impairmentsHigh-negative symptom groupSocial cognitionNegative-symptom groupNegative symptomsCaruso Emotional Intelligence TestSocial cognitive measuresEmotional Intelligence TestSocial cognitive factorsCognitive impairmentSymptom groupsNegative symptom factorMayer-SaloveyCommon assessment instrumentsCognitive factorsCognitive measuresSubstance abuse historyIntelligence testsCore featuresAbuse historyIndependent dimensionsDistinct factorsSymptom factorsSuccessful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia
Surti TS, Corbera S, Bell MD, Wexler BE. Successful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia. Schizophrenia Research 2011, 132: 131-134. PMID: 21795025, PMCID: PMC3195942, DOI: 10.1016/j.schres.2011.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansMaleMemory DisordersMiddle AgedNeuropsychological TestsPhotic StimulationSchizophreniaTherapy, Computer-AssistedVerbal LearningVisual PerceptionConceptsCognitive remediationCognitive control trainingEarly visual processingVerbal memory improvementVerbal learningAuditory learningVisual learningCognitive gainsVisual processingMemory enhancementVisual trainingCognitive outcomesMemory improvementControl trainingNeuropsychological testingVisual informationMultiple modalitiesTraining exercisesLearningInformation manipulationTrainingSchizophreniaGeneralizesTaskParticipantsHeterogeneity of Auditory Verbal Working Memory in Schizophrenia
Bruder GE, Alschuler DM, Kroppmann CJ, Fekri S, Gil RB, Jarskog LF, Harkavy-Friedman JM, Goetz R, Kayser J, Wexler BE. Heterogeneity of Auditory Verbal Working Memory in Schizophrenia. Journal Of Psychopathology And Clinical Science 2011, 120: 88-97. PMID: 21319926, PMCID: PMC3061570, DOI: 10.1037/a0021661.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAttentionAuditory PerceptionHumansMemory, Short-TermNeuropsychological TestsSchizophreniaVerbal LearningConceptsVerbal WM deficitsVerbal WMSustained attentionWM deficitsLanguage-related cortical regionsWechsler Memory Scale-RevisedAuditory hallucinationsAuditory-verbal WMVerbal Working MemoryVerbal memory deficitsGeneralized cognitive deficitHeterogeneity of schizophreniaExplicit memoryWorking memoryNonverbal memoryVisual memoryTone discriminationNonverbal testsAttentional dysfunctionAuditory perceptionSpecific deficitsCognitive deficitsMemory deficitsDiscrimination performanceMarked deficit
2010
Social attribution test — multiple choice (SAT-MC) in schizophrenia: Comparison with community sample and relationship to neurocognitive, social cognitive and symptom measures
Bell MD, Fiszdon JM, Greig TC, Wexler BE. Social attribution test — multiple choice (SAT-MC) in schizophrenia: Comparison with community sample and relationship to neurocognitive, social cognitive and symptom measures. Schizophrenia Research 2010, 122: 164-171. PMID: 20400268, PMCID: PMC2908733, DOI: 10.1016/j.schres.2010.03.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceChoice BehaviorCognition DisordersDisability EvaluationFemaleHumansInterpersonal RelationsLogistic ModelsMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesReproducibility of ResultsResidence CharacteristicsROC CurveSchizophreniaSchizophrenic PsychologySocial PerceptionConceptsSocial Attribution Task-Multiple ChoiceSocial cognitive measuresCognitive measuresAffect recognitionCommunity sampleSocial cognitive impairmentsTheory of mindSignificant group differencesMATRICS batteryNeurocognitive measuresSCZ participantsVerbal processesAutism researchCognition indexLongitudinal designSymptom measuresGroup differencesCognitive impairmentCommunity-dwelling participantsGeometric figuresSchizoaffective disorderParticipantsSchizophreniaImpairmentMultiple-choice questionsMemory profiles in schizophrenia: Categorization validity and stability
Bell MD, Johannesen JK, Greig TC, Wexler BE. Memory profiles in schizophrenia: Categorization validity and stability. Schizophrenia Research 2010, 118: 26-33. PMID: 20085855, PMCID: PMC3699867, DOI: 10.1016/j.schres.2009.12.037.Peer-Reviewed Original ResearchConceptsSocial cognitive domainsMemory profileCognitive domainsHopkins Verbal LearningCluster analytic techniquesSocial cognitionVerbal learningVerbal memorySubcortical impairmentNeuropsychological assessmentCommunity mental health centerCortical impairmentMental health centersSchizoaffective disorderMotor speedCurrent studySchizophreniaIllness characteristicsMemoryUrban community mental health centerImpairmentSimple decision rulesCognitionCluster analysisCluster groups
2008
Predictors of change in life skills in schizophrenia after cognitive remediation
Kurtz MM, Seltzer JC, Fujimoto M, Shagan DS, Wexler BE. Predictors of change in life skills in schizophrenia after cognitive remediation. Schizophrenia Research 2008, 107: 267-274. PMID: 19006657, PMCID: PMC3399665, DOI: 10.1016/j.schres.2008.10.014.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAttentionCognition DisordersComprehensionComputer-Assisted InstructionFemaleHumansInhibition, PsychologicalMemory, Short-TermMiddle AgedNeuropsychological TestsProblem SolvingPrognosisPsychiatric Status Rating ScalesPsychometricsPsychomotor PerformanceRemedial TeachingSchizophreniaSchizophrenic PsychologySocializationSoftwareVerbal LearningYoung AdultConceptsCognitive remediationAuditory attentionPerformance-based measuresRemediation interventionsComputer-assisted cognitive remediationLife skillsCognitive remediation interventionsSustained auditory attentionEveryday life skillsTreatment-related improvementTreatment process variablesOutpatient rehabilitation treatmentPredictors of changeMeasures of symptomsVerbal abilityVerbal learningTreatment outcome measuresNeurocognitive variablesNeurocognitive functionMemoryNegative symptomsSchizoaffective disorderPredictor studiesCurrent studySchizophreniaNeuropsychological Near Normality and Brain Structure Abnormality in Schizophrenia
Wexler BE, Zhu H, Bell MD, Nicholls SS, Fulbright RK, Gore JC, Colibazzi T, Amat J, Bansal R, Peterson BS. Neuropsychological Near Normality and Brain Structure Abnormality in Schizophrenia. American Journal Of Psychiatry 2008, 166: 189-195. PMID: 18765481, PMCID: PMC4288572, DOI: 10.1176/appi.ajp.2008.08020258.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsComparison subjectsCognitive deficitsCalifornia Verbal Learning TestScores one standard deviationTests of attentionVerbal Learning TestContinuous Performance TestLarger third ventricle volumesMixed-model multivariate analysisSmaller gray matterWhite matterVentricle volumeSevere cognitive deficitsBrain structure abnormalitiesGray matterLearning TestLarger lateral ventricle volumesCognitive testsThird ventricle volumesLateral ventricle volumeWhite matter pathologySmaller white matterImpaired groupNeuropsychological testingNeurocognitive enhancement therapy with vocational services: Work outcomes at two-year follow-up
Bell MD, Zito W, Greig T, Wexler BE. Neurocognitive enhancement therapy with vocational services: Work outcomes at two-year follow-up. Schizophrenia Research 2008, 105: 18-29. PMID: 18715755, DOI: 10.1016/j.schres.2008.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognition DisordersCognitive Behavioral TherapyCombined Modality TherapyEmploymentEmployment, SupportedFemaleFollow-Up StudiesHumansMaleNeuropsychological TestsOccupational TherapyPsychiatric Status Rating ScalesPsychotherapy, GroupPsychotic DisordersRehabilitation, VocationalSchizophreniaSchizophrenic PsychologyTreatment OutcomeVocational EducationConceptsNeurocognitive enhancement therapyEnhancement therapyComputer-based cognitive trainingCommunity-based vocational servicesWeekly support groupsCognitive remediationCognitive trainingExecutive functionWork outcomesRemediation programVocational outcomesCommunity mental health centerMental health centersCognitive impairmentSixth quarterVocational servicesNet trainingTherapy outcomeSupport groupsCompetitive employmentSchizophreniaRehabilitation methodsSchizoaffective patientsEmployment programsTrainingSymptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation
Kurtz MM, Wexler BE, Fujimoto M, Shagan DS, Seltzer JC. Symptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation. Schizophrenia Research 2008, 102: 303-311. PMID: 18495433, PMCID: PMC2519168, DOI: 10.1016/j.schres.2008.03.023.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAmbulatory CareCognition DisordersCognitive Behavioral TherapyFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyTherapy, Computer-AssistedVerbal LearningConceptsEveryday life skillsPerformance-based measuresLife skillsVerbal learningVerbal abilityCognitive rehabilitation interventionLongitudinal studyPredictors of changeMeasures of symptomsCognitive interventionsVisual vigilanceSustained vigilanceProcessing speedNeurocognitive deficitsNeurocognitive functionNegative symptomsBody of literatureNeurocognitionSkillsRehabilitation interventionsSchizoaffective disorderOutpatient rehabilitationCurrent studySchizophreniaRehabilitation strategies
2007
Predictors of on-site vocational support for people with schizophrenia in supported employment
Zito W, Greig TC, Wexler BE, Bell MD. Predictors of on-site vocational support for people with schizophrenia in supported employment. Schizophrenia Research 2007, 94: 81-88. PMID: 17512172, PMCID: PMC1986779, DOI: 10.1016/j.schres.2007.03.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognition DisordersEmployment, SupportedFemaleHumansMaleMiddle AgedNeuropsychological TestsRehabilitation, VocationalSchizophreniaSeverity of Illness IndexNeurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance
Bell M, Fiszdon J, Greig T, Wexler B, Bryson G. Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance. The Journal Of Rehabilitation Research And Development 2007, 44: 761. PMID: 17943687, DOI: 10.1682/jrrd.2007.02.0032.Peer-Reviewed Original ResearchConceptsNeurocognitive enhancement therapyWork therapyEnhancement therapyExecutive function tasksComputer-based trainingNonverbal memoryFunction tasksExecutive functionNeuropsychological performanceNeuropsychological testsNeuropsychological assessmentCognitive deficitsCompletion of trainingNeuropsychological improvementOccupational dysfunctionMemorySchizoaffective disorderCurrent studySchizophreniaTrainingJob placementWork activitiesActive interventionTaskAnalysis of variance