2011
Successful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia
Surti TS, Corbera S, Bell MD, Wexler BE. Successful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia. Schizophrenia Research 2011, 132: 131-134. PMID: 21795025, PMCID: PMC3195942, DOI: 10.1016/j.schres.2011.06.031.Peer-Reviewed Original ResearchConceptsCognitive remediationCognitive control trainingEarly visual processingVerbal memory improvementVerbal learningAuditory learningVisual learningCognitive gainsVisual processingMemory enhancementVisual trainingCognitive outcomesMemory improvementControl trainingNeuropsychological testingVisual informationMultiple modalitiesTraining exercisesLearningInformation manipulationTrainingSchizophreniaGeneralizesTaskParticipants
2010
Memory profiles in schizophrenia: Categorization validity and stability
Bell MD, Johannesen JK, Greig TC, Wexler BE. Memory profiles in schizophrenia: Categorization validity and stability. Schizophrenia Research 2010, 118: 26-33. PMID: 20085855, PMCID: PMC3699867, DOI: 10.1016/j.schres.2009.12.037.Peer-Reviewed Original ResearchConceptsSocial cognitive domainsMemory profileCognitive domainsHopkins Verbal LearningCluster analytic techniquesSocial cognitionVerbal learningVerbal memorySubcortical impairmentNeuropsychological assessmentCommunity mental health centerCortical impairmentMental health centersSchizoaffective disorderMotor speedCurrent studySchizophreniaIllness characteristicsMemoryUrban community mental health centerImpairmentSimple decision rulesCognitionCluster analysisCluster groups
2006
Neuropsychological deficits in nonsmokers with schizophrenia: Effects of a nicotinic antagonist
Sacco KA, Termine A, Dudas MM, Seyal AA, Allen TM, Vessicchio JC, Wexler BE, George TP. Neuropsychological deficits in nonsmokers with schizophrenia: Effects of a nicotinic antagonist. Schizophrenia Research 2006, 85: 213-221. PMID: 16678390, DOI: 10.1016/j.schres.2006.03.025.Peer-Reviewed Original ResearchConceptsWisconsin Card Sorting TestContinuous Performance TestControl nonsmokersNeuropsychological performanceStroop Color-Word TestNeuropsychological deficitsNicotinic acetylcholine receptor systemAcetylcholine receptor systemPosition testVisuospatial working memoryCigarette smokingAntagonist mecamylamineNicotinic antagonistsNeuropsychological dysfunctionNAChR blockadeNonsmokersSchizophrenia diagnosisColor-Word TestMecamylamineReceptor systemNeuropsychological assessmentSchizophreniaCard Sorting TestCounterbalanced designTest week
2005
Effects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms
Sacco KA, Termine A, Seyal A, Dudas MM, Vessicchio JC, Krishnan-Sarin S, Jatlow PI, Wexler BE, George TP. Effects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms. JAMA Psychiatry 2005, 62: 649-659. PMID: 15939842, DOI: 10.1001/archpsyc.62.6.649.Peer-Reviewed Original ResearchConceptsVisuospatial working memoryWorking memoryAttentional deficitsCognitive deficitsOvernight abstinenceContinuous Performance Test scoresSpatial working memoryOutpatient mental health centersPerformance test scoresCognitive enhancementCPT performanceNeuropsychological assessmentSmoking reinstatementTobacco cravingControl smokersTest scoresCounterbalanced mannerMental health centersCognitive impairmentReinstatementSubjective effectsNicotine dependenceCigarette smokingDeficitsNicotinic receptor mechanisms
2004
Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits
Bruder GE, Wexler BE, Sage MM, Gil RB, Gorman JM. Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits. Schizophrenia Research 2004, 68: 137-147. PMID: 15099598, DOI: 10.1016/s0920-9964(03)00156-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionAuditory PerceptionCerebral CortexCognition DisordersDichotic Listening TestsDominance, CerebralFemaleFunctional LateralityHumansMaleMemory DisordersMental RecallNeuropsychological TestsPaired-Associate LearningPitch DiscriminationPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyVerbal LearningWechsler ScalesConceptsVerbal memory deficitsMemory deficitsVerbal memoryWechsler Memory Scale-RevisedNonverbal cognitive functionsDifferent cognitive deficitsSerial position effectsVerbal materialVisual memoryNonverbal testsAuditory perceptionGeneralized deficitSelective deficitDichotic wordsHemispheric dominanceCognitive deficitsCognitive functionMemoryMedication statusHealthy controlsDeficitsOverall poor performancePosition effectsPoor performancePosition testDurability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up
Fiszdon JM, Bryson GJ, Wexler BE, Bell MD. Durability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up. Psychiatry Research 2004, 125: 1-7. PMID: 14967547, DOI: 10.1016/j.psychres.2003.10.004.Peer-Reviewed Original ResearchConceptsCognitive remediation trainingSerial position taskComputerized cognitive remediationDigit span taskSpan taskRemediation trainingCognitive remediationMemory taskPosition taskComputerized cognitive remediation trainingWork therapyActive control conditionGroups of participantsSignificant group differencesComputerized trainingCognitive retrainingComputerized tasksTraining tasksCognitive improvementCognitive deficitsCompletion of trainingGroup differencesControl conditionTaskTraining
2003
Cognitive remediation of working memory deficits: durability of training effects in severely impaired and less severely impaired schizophrenia
Bell M, Bryson G, Wexler BE. Cognitive remediation of working memory deficits: durability of training effects in severely impaired and less severely impaired schizophrenia. Acta Psychiatrica Scandinavica 2003, 108: 101-109. PMID: 12823166, DOI: 10.1034/j.1600-0447.2003.00090.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyFemaleHumansMaleMemory DisordersMiddle AgedSchizophreniaSeverity of Illness IndexTreatment OutcomeConceptsNeurocognitive enhancement therapyWork therapyCognitive remediationTraining effectsSocial information processingCognitive training exercisesExecutive functionMemory performanceEnhancement therapyMemory deficitsInformation processingSeverity of impairmentDuration of trainingGreater improvementSchizoaffective disorderMemoryParticipantsTraining exercisesMost participantsImpairment severitySchizophreniaTrainingDuration of effectSeverity groupsDeficits
2002
Deficits in language-mediated mental operations in patients with schizophrenia
Wexler BE, Donegan N, Stevens AA, Jacob SA. Deficits in language-mediated mental operations in patients with schizophrenia. Schizophrenia Research 2002, 53: 171-179. PMID: 11738530, DOI: 10.1016/s0920-9964(01)00194-3.Peer-Reviewed Original ResearchConceptsMemory taskMemory deficitsMemory testFamiliar soundsNon-verbal memory testsEarly perceptual processingSerial position taskWord memory taskVerbal memory processesVerbal memory taskNon-verbal memoryVerbal memory testsPerceptual processingAttentional competenceVerbal materialVerbal stimuliStimulus itemsMemory processesMental operationsTask difficultyVisual stimuliImpaired performancePosition taskSensory processingAuditory tests
2001
Verbal Working Memory Impairment in Schizophrenia
BELL M, BRYSON G, WEXLER B. Verbal Working Memory Impairment in Schizophrenia. American Journal Of Psychiatry 2001, 158: 660-660. PMID: 11282724, DOI: 10.1176/appi.ajp.158.4.660.Peer-Reviewed Original Research
2000
Preliminary Evidence of Improved Verbal Working Memory Performance and Normalization of Task-Related Frontal Lobe Activation in Schizophrenia Following Cognitive Exercises
Wexler BE, Anderson M, Fulbright RK, Gore JC. Preliminary Evidence of Improved Verbal Working Memory Performance and Normalization of Task-Related Frontal Lobe Activation in Schizophrenia Following Cognitive Exercises. American Journal Of Psychiatry 2000, 157: 1694-1697. PMID: 11007730, DOI: 10.1176/appi.ajp.157.10.1694.Peer-Reviewed Original ResearchConceptsLeft inferior frontal cortexTask-related activationVerbal memory taskInferior frontal cortexMemory performanceMemory taskCognitive exercisesMemory exercisesNonverbal memory performanceWorking Memory PerformanceVerbal memory deficitsVerbal memory dysfunctionFrontal lobe activationRegional brain activationFrontal cortexSame brain regionsBrain activationTraining periodMemory deficitsMemory dysfunctionBrain regionsPreliminary evidenceBehavioral aspectsTaskSchizophrenia
1999
California Verbal Learning Test practice effects in a schizophrenia sample
Hawkins K, Wexler B. California Verbal Learning Test practice effects in a schizophrenia sample. Schizophrenia Research 1999, 39: 73-78. PMID: 10480669, DOI: 10.1016/s0920-9964(99)00015-8.Peer-Reviewed Original ResearchConceptsPractice effectsCalifornia Verbal Learning TestVerbal Learning TestTest practice effectsLearning TestWeek 10Sample of personsNew learningSchizophrenia sampleLater performancePrior exposureNon-pharmacological interventionsSerial performanceSample of patientsClinical circumstancesWeek 14Psychiatric statusLearningSchizophreniaCVLTExact natureMemoryConsiderable retentionLarge effectExposure
1998
Word and Tone Working Memory Deficits in Schizophrenia
Wexler BE, Stevens AA, Bowers AA, Sernyak MJ, Goldman-Rakic PS. Word and Tone Working Memory Deficits in Schizophrenia. JAMA Psychiatry 1998, 55: 1093-1096. PMID: 9862552, DOI: 10.1001/archpsyc.55.12.1093.Peer-Reviewed Original ResearchConceptsMemory testNonverbal testsVerbal testsMemory deficitsSerial position taskTests of perceptionAuditory memory testVerbal memory deficitsWorking Memory DeficitsImmediate recall taskSignificant performance deficitsRecall taskVerbal memoryPerceptual functionsSustained attentionDiscrimination taskPitch discriminationSelective deficitNormal motivationPerformance deficitsPosition taskMemory testingCognitive functionMedicated outpatientsInformation processing