2001
Functional MR imaging of regional brain activation associated with the affective experience of pain.
Fulbright R, Troche C, Skudlarski P, Gore J, Wexler B. Functional MR imaging of regional brain activation associated with the affective experience of pain. American Journal Of Roentgenology 2001, 177: 1205-10. PMID: 11641204, DOI: 10.2214/ajr.177.5.1771205.Peer-Reviewed Original ResearchConceptsAnterior cingulate gyrusSuperior frontal gyrusCingulate gyrusPain taskRight cuneusFunctional MRFrontal gyrusRight superior frontal gyrusBrain activationPain-related activationCold pressor testLeft anterior insulaExperience of painRegional brain activationFunctional MR imagingMotor-sensory areasPainful temperaturesPain thresholdLeft thalamusPressor testPainful levelsPostcentral gyrusPainFrontal lobeHealthy adultsNeurocognitive Enhancement Therapy With Work Therapy: Effects on Neuropsychological Test Performance
Bell M, Bryson G, Greig T, Corcoran C, Wexler BE. Neurocognitive Enhancement Therapy With Work Therapy: Effects on Neuropsychological Test Performance. JAMA Psychiatry 2001, 58: 763-768. PMID: 11483142, DOI: 10.1001/archpsyc.58.8.763.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCognitionCognition DisordersComputer-Assisted InstructionDichotic Listening TestsFeedbackFemaleFrontal LobeHumansMaleMemoryMultivariate AnalysisNeuropsychological TestsOccupational TherapyPsychomotor PerformancePsychotic DisordersSchizophreniaSchizophrenic PsychologyTeachingTreatment OutcomeConceptsNeurocognitive enhancement therapyEnhancement therapyWork therapyMental activityNeuropsychological testingLarge effect size improvementsExecutive function tasksNeuropsychological test performanceEffect size improvementsComputer-based trainingFunction tasksExecutive functionMemory performanceCognitive performanceNeuropsychological testsTraining tasksCognitive deficitsTest performanceComputer trainingCognitive dysfunctionIndependent outcome measureOccupational dysfunctionNatural contextSchizoaffective disorderMemoryFunctional Magnetic Resonance Imaging of Cocaine Craving
Wexler BE, Gottschalk CH, Fulbright RK, Prohovnik I, Lacadie CM, Rounsaville BJ, Gore JC. Functional Magnetic Resonance Imaging of Cocaine Craving. American Journal Of Psychiatry 2001, 158: 86-95. PMID: 11136638, DOI: 10.1176/appi.ajp.158.1.86.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingHealthy subjectsCocaine-dependent subjectsMagnetic resonance imagingResonance imagingCocaine addictsReported onsetBrain activationBrain activityRegional brain activationFrontal lobe activationAnterior cingulate activationNeurobiology of addictionCocaine cravingAnterior cingulatePatientsFrontal lobePhysiologic linkSensory areasComparison of groupsDrug cravingDysphoric statesLess activationGeneral abnormalityCingulate activation
2000
Preliminary Evidence of Improved Verbal Working Memory Performance and Normalization of Task-Related Frontal Lobe Activation in Schizophrenia Following Cognitive Exercises
Wexler BE, Anderson M, Fulbright RK, Gore JC. Preliminary Evidence of Improved Verbal Working Memory Performance and Normalization of Task-Related Frontal Lobe Activation in Schizophrenia Following Cognitive Exercises. American Journal Of Psychiatry 2000, 157: 1694-1697. PMID: 11007730, DOI: 10.1176/appi.ajp.157.10.1694.Peer-Reviewed Original ResearchConceptsLeft inferior frontal cortexTask-related activationVerbal memory taskInferior frontal cortexMemory performanceMemory taskCognitive exercisesMemory exercisesNonverbal memory performanceWorking Memory PerformanceVerbal memory deficitsVerbal memory dysfunctionFrontal lobe activationRegional brain activationFrontal cortexSame brain regionsBrain activationTraining periodMemory deficitsMemory dysfunctionBrain regionsPreliminary evidenceBehavioral aspectsTaskSchizophrenia
1998
Cortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging
Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler BE. Cortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging. JAMA Psychiatry 1998, 55: 1097-1103. PMID: 9862553, DOI: 10.1001/archpsyc.55.12.1097.Peer-Reviewed Original ResearchConceptsSerial position taskFunctional magnetic resonance imagingInferior frontal gyrusPosition taskMemory deficitsFrontal gyrusLeft inferior frontal gyrusAnterior temporal lobe areasTask-specific activationFunctional magnetic resonanceSpeech-related areasCortical hemodynamic responsesTemporal lobe areasSevere cognitive deficitsAuditory wordsWorking memoryVerbal learningNeural basisSuch deficitsCognitive deficitsCognitive functionParietal lobeLobe areasMagnetic resonance imagingCognitive dysfunctionFunctional MR imaging of regional brain responses to pleasant and unpleasant odors.
Fulbright RK, Skudlarski P, Lacadie CM, Warrenburg S, Bowers AA, Gore JC, Wexler BE. Functional MR imaging of regional brain responses to pleasant and unpleasant odors. American Journal Of Neuroradiology 1998, 19: 1721-6. PMID: 9802496, PMCID: PMC8337499.Peer-Reviewed Original ResearchConceptsFunctional MR imagingArea 8BA 6MR imagingBrodmann area 8Human cerebral cortexRegional brain responsesMedial temporal lobeTemporal brain regionsLeft BA 6Independent t-testCerebral cortexTemporal lobeBA 32Cortical areasLeft insulaAnterior temporal brain regionsBrain regionsOrbitofrontal cortexNormal adultsIsovaleric acidOlfactory networkMore activityAir trialsBrain responses