2020
An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder
Wexler BE, Vitulano LA, Moore C, Katsovich L, Smith SD, Rush C, Grantz H, Dong J, Leckman JF. An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder. Psychological Medicine 2020, 51: 1524-1535. PMID: 32090720, DOI: 10.1017/s0033291720000288.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderExperimental medicine approachTAU groupMedicine approachHyperactivity disorderWeeks of treatmentCombined subtypeDiagnosis of ADHDClinical trial designHyperactive-impulsive subtypeAttention-deficit/hyperactivity disorderCross-over designDeficit hyperactivity disorderClinical improvementClinical symptomsRandomized crossCognitive dysfunctionCT groupPathophysiological heterogeneityCONSORT recommendationsTrial designResponse rateChange scoresSubtypesTargeted pathology
2019
Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence
Kavanaugh BC, Cancilliere MK, Fryc A, Tirrell E, Oliveira J, Oberman LM, Wexler BE, Carpenter LL, Spirito A. Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence. Child Neuropsychology 2019, 26: 754-769. PMID: 31876232, PMCID: PMC10629577, DOI: 10.1080/09297049.2019.1708295.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomatologyGlobal deficit scoreDepressive symptomatologyDetection of impairmentHealth ToolboxDepressive symptom varianceNational InstituteChildhood/adolescenceSelf-reported depressionComparable psychometric propertiesSymptom varianceEF symptomsDeficit scoresDepression diagnosisDepressive symptomsClinical diagnosisChild-reported anxietyClinical neuropsychological measuresImpairmentMeasures of EFSymptomatologyDepressionNeuropsychological measuresSymptomsParent reportThe development of adaptive risk taking and the role of executive functions in a large sample of school-age boys and girls
Bell MD, Imal AE, Pittman B, Jin G, Wexler BE. The development of adaptive risk taking and the role of executive functions in a large sample of school-age boys and girls. Trends In Neuroscience And Education 2019, 17: 100120. PMID: 31685124, DOI: 10.1016/j.tine.2019.100120.Peer-Reviewed Original ResearchConceptsBalloon Analogue Risk TaskSchool-aged boysExecutive functionRisk TaskPartial mediatorAcademic achievementRisk takingBetter mathChild's schoolSchool characteristicsMiddle schoolLarge sampleTotal scoreSchoolsRecklessnessChildrenBoysBetter decisionsEmotionsGradeMeasuresFunctioningTaskProficiencyTaking
2016
Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression
Morimoto SS, Gunning FM, Wexler BE, Hu W, Ilieva I, Liu J, Nitis J, Alexopoulos GS. Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression. American Journal Of Geriatric Psychiatry 2016, 24: 816-820. PMID: 27591163, PMCID: PMC5873289, DOI: 10.1016/j.jagp.2016.06.010.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionCognitive remediation interventionsComputerized cognitive remediationPoor treatment responseFavorable treatment responseTreatment responseCognitive remediationRemediation interventionsMajor depressionNeuropsychological performanceElderly patientsOlder adultsLate-life depressionMontgomery-Asberg Depression Rating Scale scoreTreatment-resistant major depressionDepression Rating Scale scoresRating Scale scoresDepressionAntidepressant treatmentTreatment trialsScale scorePatientsBaselineGreater reductionDysfunction
2014
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nature Communications 2014, 5: 4579. PMID: 25093396, PMCID: PMC4139707, DOI: 10.1038/ncomms5579.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionExecutive functionGeriatric depressionComputerized cognitive remediationTreatment-resistant geriatric depressionHistorical controlsBrain network abnormalitiesCognitive remediationPoor clinical outcomeGold standard treatmentRemission of symptomsOlder adultsClinical outcomesDepression treatmentMajor depressionDepressive symptomsNetwork abnormalitiesEscitalopramDepressionSymptomsGreater improvementTreatmentDeficitsRemissionParticipants
2012
Neuroplasticity‐based computerized cognitive remediation for geriatric depression
Morimoto SS, Wexler BE, Alexopoulos GS. Neuroplasticity‐based computerized cognitive remediation for geriatric depression. International Journal Of Geriatric Psychiatry 2012, 27: 1239-1247. PMID: 22451346, PMCID: PMC3387346, DOI: 10.1002/gps.3776.Peer-Reviewed Original ResearchConceptsComputerized cognitive remediationCognitive remediationExecutive dysfunctionGeriatric depressionSpecific executive deficitsSpecific neurocognitive deficitsSpecific cerebral networksNovel treatment interventionsAvailable treatment studiesNovel treatment modelExecutive deficitsEmotional regulationNeurocognitive deficitsUnderlying neurobiologyMental health reportsCerebral networksOlder adultsTreatment modelTreatment interventionsDepressed eldersTreatment studiesBehavioral changesNew interventionsDepressionDeficits