2018
Measuring theory of mind in schizophrenia research: Cross-cultural validation
Lee HS, Corbera S, Poltorak A, Park K, Assaf M, Bell MD, Wexler BE, Cho YI, Jung S, Brocke S, Choi KH. Measuring theory of mind in schizophrenia research: Cross-cultural validation. Schizophrenia Research 2018, 201: 187-195. PMID: 29958750, DOI: 10.1016/j.schres.2018.06.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Cultural ComparisonFemaleHumansMaleNorth AmericaPsychometricsRepublic of KoreaSchizophreniaSchizophrenic PsychologySocial PerceptionTheory of MindConceptsSocial Attribution Task-Multiple ChoiceTheory of mindSocial cognition measuresSocial cognition tasksSocial cognitive impairmentsSchizophrenia researchInternal consistencyConvergent/divergent validityConfirmatory factor analysisGood internal consistencyOne-factor modelCognition measuresCognition tasksIndividual differencesGood model fitCross-cultural validationMental statesMeasurement invarianceDivergent validityDiscriminant validityToMFactor structureHealthy controlsCognitive impairmentDiverse languages
2016
Cognitive remediation for adults with schizophrenia: Does age matter?
Corbera S, Wexler BE, Poltorak A, Thime WR, Kurtz MM. Cognitive remediation for adults with schizophrenia: Does age matter? Psychiatry Research 2016, 247: 21-27. PMID: 27863314, PMCID: PMC5248553, DOI: 10.1016/j.psychres.2016.10.084.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsCognition DisordersCognitive RemediationFemaleHumansMaleMemory, Short-TermSchizophreniaSchizophrenic PsychologyTreatment OutcomeYoung AdultConceptsCognitive remediationSubstantial individual differencesEarly chronic groupsOlder client populationNovel behavioral interventionSubsample of clientsRole of ageMemory measuresIndividual differencesStrategy acquisitionCognitive outcomesCognitive deficitsTask practiceRandomized control trialBehavioral interventionsTrend levelEmpirical supportSchizophreniaTreatment responseAge matterClient populationEarly-stage groupAge rangeGreater improvementAdults
2015
Social skills training and computer-assisted cognitive remediation in schizophrenia
Kurtz MM, Mueser KT, Thime WR, Corbera S, Wexler BE. Social skills training and computer-assisted cognitive remediation in schizophrenia. Schizophrenia Research 2015, 162: 35-41. PMID: 25640526, PMCID: PMC5146951, DOI: 10.1016/j.schres.2015.01.020.Peer-Reviewed Original ResearchConceptsActive control conditionCognitive remediationComputer-assisted cognitive remediationComputer skills training programEvidence-based psychosocial interventionsCognitive remediation interventionsSocial skills trainingControl conditionSkills training programPerformance-based measuresRehabilitation interventionsStrategy trainingBody of researchNeurocognitive measuresRemediation interventionsSocial skillsSST programPsychosocial functioningPsychosocial interventionsSkills trainingImproved empathySkill groupsNeurocognitive functionPsychosocial functionTraining program
2014
Physiological evidence of a deficit to enhance the empathic response in schizophrenia
Corbera S, Ikezawa S, Bell MD, Wexler BE. Physiological evidence of a deficit to enhance the empathic response in schizophrenia. European Psychiatry 2014, 29: 463-472. PMID: 24630376, DOI: 10.1016/j.eurpsy.2014.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesCognitionEmpathyEvoked PotentialsFemaleHumansMaleMiddle AgedPsychological TestsReaction TimeSchizophreniaSchizophrenic PsychologyConceptsEvent-related potentialsEmpathic responsesERP responsesPersonal distressRegulatory deficitsLate cognitive componentsSocial cognition processesPictures of handsEffective social interactionsLate ERP responsesOwn emotional engagementCognitive empathyTask demandsPerspective takingCognition processEmpathic conditionEmotional engagementSocial situationsSocial interactionEmpathyPainful situationsSubjective ratingsOwn painPain paradigmDistressIncreasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits
Wexler BE, Ikezawa S, Corbera S. Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits. Schizophrenia Research 2014, 158: 163-169. PMID: 25096541, PMCID: PMC4240766, DOI: 10.1016/j.schres.2014.07.012.Peer-Reviewed Original ResearchConceptsHealthy controlsCognitive deficitsMs stimuliStructured Clinical InterviewDSM-IV criteriaModulation of responsesStimulus durationPictures of handsEvent Related PotentialsAdult outpatientsPain stimuliHealthy peoplePatientsClinical InterviewSchizoaffective disorderSchizophreniaMs stimulusSensory inputStimulus onsetSame durationDurationStimuliDeficitsResponseNeutral stimuliNeural activation abnormalities during self-referential processing in schizophrenia: An fMRI study
Liu J, Corbera S, Wexler BE. Neural activation abnormalities during self-referential processing in schizophrenia: An fMRI study. Psychiatry Research 2014, 222: 165-171. PMID: 24795158, DOI: 10.1016/j.pscychresns.2014.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCerebral CortexFemaleHumansLanguageMagnetic Resonance ImagingMaleMiddle AgedMothersSchizophreniaSchizophrenic PsychologyUnited StatesConceptsActivation abnormalitiesHealthy controlsCortical midline structuresMidline structuresBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFunctional magnetic resonanceGeneral neuropathologySchizophrenia altersTemporal gyrusPatientsAbnormalitiesSchizophreniaActivation paradigmGreater signal increaseGroup differencesFMRI studyPosterior regionSelf-referential processingMothersMagnetic resonanceDependent signalsNeuropathologyControlGyrus
2013
Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia
Colibazzi T, Wexler BE, Bansal R, Hao X, Liu J, Sanchez-Peña J, Corcoran C, Lieberman JA, Peterson BS. Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia. PLOS ONE 2013, 8: e55783. PMID: 23418459, PMCID: PMC3572102, DOI: 10.1371/journal.pone.0055783.Peer-Reviewed Original ResearchConceptsCortical thicknessWhite matterCortical surface areaGray matterAnatomical abnormalitiesGM volumeWM abnormalitiesContribution of abnormalitiesRegional GM volumeHealthy controlsHigh burdenCingulate gyrusTotal cortical surface areaThinner cortexSuperior frontalAbnormalitiesLocation of abnormalitiesPerisylvian cortexSchizophreniaWM surfaceBrainCortical surfaceBrain anatomyPatientsSerial position task
2012
Empathy in electrodermal responsive and nonresponsive patients with schizophrenia
Ikezawa S, Corbera S, Liu J, Wexler BE. Empathy in electrodermal responsive and nonresponsive patients with schizophrenia. Schizophrenia Research 2012, 142: 71-76. PMID: 23058162, PMCID: PMC3502678, DOI: 10.1016/j.schres.2012.09.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAntipsychotic AgentsChlorpromazineElectroencephalographyEmpathyEvoked PotentialsFemaleGalvanic Skin ResponseHumansMaleMiddle AgedNeuropsychological TestsPersonality TestsPsychiatric Status Rating ScalesPsychotic DisordersRecognition, PsychologySchizophreniaSchizophrenic PsychologySocial BehaviorConceptsSkin conductance responsesEvent Related PotentialsSocial cognitionEmotion-evoking stimuliHealthy controlsPictures of peopleAssessment of symptomsERP responsesPersonal distressConductance responsesRelated potentialsNonresponsive patientsSchizophrenia patientsSCR frequencyCognitionPatientsSocial functionSocial integrationPotential markerSchizophreniaDistressPainPrognosisSubgroupsSymptomsComputerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study
Murthy NV, Mahncke H, Wexler BE, Maruff P, Inamdar A, Zucchetto M, Lund J, Shabbir S, Shergill S, Keshavan M, Kapur S, Laruelle M, Alexander R. Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study. Schizophrenia Research 2012, 139: 87-91. PMID: 22342330, DOI: 10.1016/j.schres.2012.01.042.Peer-Reviewed Original ResearchConceptsFunctional capacity outcome measuresCognitive Assessment InterviewBrain Fitness ProgramSignificant treatment effectOutcome measuresRegular antipsychotic medicationStable adult patientsNon-pharmacological methodsCognitive performanceTreatment effectsComputerized cognitive remediation trainingMultinational clinical trialsSingle-site studyTraining effectsCognitive remediation trainingOpen labelAdult patientsAntipsychotic medicationCAI scoreClinical trialsCognitive impairmentMulti-site studyExercise taskRemediation trainingNeuropsychological tasks
2011
Social Cognitive Impairments and Negative Symptoms in Schizophrenia: Are There Subtypes With Distinct Functional Correlates?
Bell MD, Corbera S, Johannesen JK, Fiszdon JM, Wexler BE. Social Cognitive Impairments and Negative Symptoms in Schizophrenia: Are There Subtypes With Distinct Functional Correlates? Schizophrenia Bulletin 2011, 39: 186-196. PMID: 21976710, PMCID: PMC3523908, DOI: 10.1093/schbul/sbr125.Peer-Reviewed Original ResearchConceptsHigher social cognitionLower social cognitionSocial cognitive impairmentsHigh-negative symptom groupSocial cognitionNegative-symptom groupNegative symptomsCaruso Emotional Intelligence TestSocial cognitive measuresEmotional Intelligence TestSocial cognitive factorsCognitive impairmentSymptom groupsNegative symptom factorMayer-SaloveyCommon assessment instrumentsCognitive factorsCognitive measuresSubstance abuse historyIntelligence testsCore featuresAbuse historyIndependent dimensionsDistinct factorsSymptom factors
2010
Social attribution test — multiple choice (SAT-MC) in schizophrenia: Comparison with community sample and relationship to neurocognitive, social cognitive and symptom measures
Bell MD, Fiszdon JM, Greig TC, Wexler BE. Social attribution test — multiple choice (SAT-MC) in schizophrenia: Comparison with community sample and relationship to neurocognitive, social cognitive and symptom measures. Schizophrenia Research 2010, 122: 164-171. PMID: 20400268, PMCID: PMC2908733, DOI: 10.1016/j.schres.2010.03.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceChoice BehaviorCognition DisordersDisability EvaluationFemaleHumansInterpersonal RelationsLogistic ModelsMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesReproducibility of ResultsResidence CharacteristicsROC CurveSchizophreniaSchizophrenic PsychologySocial PerceptionConceptsSocial Attribution Task-Multiple ChoiceSocial cognitive measuresCognitive measuresAffect recognitionCommunity sampleSocial cognitive impairmentsTheory of mindSignificant group differencesMATRICS batteryNeurocognitive measuresSCZ participantsVerbal processesAutism researchCognition indexLongitudinal designSymptom measuresGroup differencesCognitive impairmentCommunity-dwelling participantsGeometric figuresSchizoaffective disorderParticipantsSchizophreniaImpairmentMultiple-choice questionsMemory profiles in schizophrenia: Categorization validity and stability
Bell MD, Johannesen JK, Greig TC, Wexler BE. Memory profiles in schizophrenia: Categorization validity and stability. Schizophrenia Research 2010, 118: 26-33. PMID: 20085855, PMCID: PMC3699867, DOI: 10.1016/j.schres.2009.12.037.Peer-Reviewed Original ResearchConceptsSocial cognitive domainsMemory profileCognitive domainsHopkins Verbal LearningCluster analytic techniquesSocial cognitionVerbal learningVerbal memorySubcortical impairmentNeuropsychological assessmentCommunity mental health centerCortical impairmentMental health centersSchizoaffective disorderMotor speedCurrent studySchizophreniaIllness characteristicsMemoryUrban community mental health centerImpairmentSimple decision rulesCognitionCluster analysisCluster groups
2008
Predictors of change in life skills in schizophrenia after cognitive remediation
Kurtz MM, Seltzer JC, Fujimoto M, Shagan DS, Wexler BE. Predictors of change in life skills in schizophrenia after cognitive remediation. Schizophrenia Research 2008, 107: 267-274. PMID: 19006657, PMCID: PMC3399665, DOI: 10.1016/j.schres.2008.10.014.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAttentionCognition DisordersComprehensionComputer-Assisted InstructionFemaleHumansInhibition, PsychologicalMemory, Short-TermMiddle AgedNeuropsychological TestsProblem SolvingPrognosisPsychiatric Status Rating ScalesPsychometricsPsychomotor PerformanceRemedial TeachingSchizophreniaSchizophrenic PsychologySocializationSoftwareVerbal LearningYoung AdultConceptsCognitive remediationAuditory attentionPerformance-based measuresRemediation interventionsComputer-assisted cognitive remediationLife skillsCognitive remediation interventionsSustained auditory attentionEveryday life skillsTreatment-related improvementTreatment process variablesOutpatient rehabilitation treatmentPredictors of changeMeasures of symptomsVerbal abilityVerbal learningTreatment outcome measuresNeurocognitive variablesNeurocognitive functionMemoryNegative symptomsSchizoaffective disorderPredictor studiesCurrent studySchizophreniaNeurocognitive enhancement therapy with vocational services: Work outcomes at two-year follow-up
Bell MD, Zito W, Greig T, Wexler BE. Neurocognitive enhancement therapy with vocational services: Work outcomes at two-year follow-up. Schizophrenia Research 2008, 105: 18-29. PMID: 18715755, DOI: 10.1016/j.schres.2008.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognition DisordersCognitive Behavioral TherapyCombined Modality TherapyEmploymentEmployment, SupportedFemaleFollow-Up StudiesHumansMaleNeuropsychological TestsOccupational TherapyPsychiatric Status Rating ScalesPsychotherapy, GroupPsychotic DisordersRehabilitation, VocationalSchizophreniaSchizophrenic PsychologyTreatment OutcomeVocational EducationConceptsNeurocognitive enhancement therapyEnhancement therapyComputer-based cognitive trainingCommunity-based vocational servicesWeekly support groupsCognitive remediationCognitive trainingExecutive functionWork outcomesRemediation programVocational outcomesCommunity mental health centerMental health centersCognitive impairmentSixth quarterVocational servicesNet trainingTherapy outcomeSupport groupsCompetitive employmentSchizophreniaRehabilitation methodsSchizoaffective patientsEmployment programsTrainingSymptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation
Kurtz MM, Wexler BE, Fujimoto M, Shagan DS, Seltzer JC. Symptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation. Schizophrenia Research 2008, 102: 303-311. PMID: 18495433, PMCID: PMC2519168, DOI: 10.1016/j.schres.2008.03.023.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAmbulatory CareCognition DisordersCognitive Behavioral TherapyFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyTherapy, Computer-AssistedVerbal LearningConceptsEveryday life skillsPerformance-based measuresLife skillsVerbal learningVerbal abilityCognitive rehabilitation interventionLongitudinal studyPredictors of changeMeasures of symptomsCognitive interventionsVisual vigilanceSustained vigilanceProcessing speedNeurocognitive deficitsNeurocognitive functionNegative symptomsBody of literatureNeurocognitionSkillsRehabilitation interventionsSchizoaffective disorderOutpatient rehabilitationCurrent studySchizophreniaRehabilitation strategies
2007
Improved cognitive function in schizophrenia after one year of cognitive training and vocational services
Greig TC, Zito W, Wexler BE, Fiszdon J, Bell MD. Improved cognitive function in schizophrenia after one year of cognitive training and vocational services. Schizophrenia Research 2007, 96: 156-161. PMID: 17669629, PMCID: PMC2080620, DOI: 10.1016/j.schres.2007.07.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitionCognitive Behavioral TherapyEthnicityFemaleHumansMaleOutpatientsPsychotic DisordersRehabilitation, VocationalSchizophreniaSchizophrenic PsychologyConceptsNeurocognitive enhancement therapyCognitive training exercisesCognitive remediation programNeuropsychological test batterySchizoaffective disorderCognitive trainingExecutive functionEnhancement therapyTest batteryCognitive functionCognitive deficitsRemediation programVocational programsCommunity mental health centerYear-long programMental health centersFeedback groupVocational servicesStable outpatientsParticipantsSchizophreniaTraining exercisesProcessing groupUrban community mental health centerSupport programsNeurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance
Bell M, Fiszdon J, Greig T, Wexler B, Bryson G. Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance. The Journal Of Rehabilitation Research And Development 2007, 44: 761. PMID: 17943687, DOI: 10.1682/jrrd.2007.02.0032.Peer-Reviewed Original ResearchConceptsNeurocognitive enhancement therapyWork therapyEnhancement therapyExecutive function tasksComputer-based trainingNonverbal memoryFunction tasksExecutive functionNeuropsychological performanceNeuropsychological testsNeuropsychological assessmentCognitive deficitsCompletion of trainingNeuropsychological improvementOccupational dysfunctionMemorySchizoaffective disorderCurrent studySchizophreniaTrainingJob placementWork activitiesActive interventionTaskAnalysis of variance
2006
Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient?
Kurtz MM, Seltzer JC, Shagan DS, Thime WR, Wexler BE. Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient? Schizophrenia Research 2006, 89: 251-260. PMID: 17070671, PMCID: PMC2095777, DOI: 10.1016/j.schres.2006.09.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCognition DisordersComputer User TrainingComputer-Assisted InstructionFemaleHumansMaleMemory, Short-TermMental RecallMiddle AgedNeuropsychological TestsPattern Recognition, VisualProblem SolvingReaction TimeRemedial TeachingSchizophreniaSchizophrenic LanguageSchizophrenic PsychologySpeech PerceptionConceptsComputer-assisted cognitive remediationTraining control conditionCognitive remediationNeurocognitive functionComprehensive neuropsychological test batteryCognitive remediation interventionsCognitive remediation trainingSpatial episodic memoryControl conditionNeuropsychological test batteryEpisodic memoryComplex behavioral treatmentsBody of researchCognitive stimulationRemediation interventionsCognitive challengesNeurocognitive testsProcessing speedBehavioral treatmentTest batteryMemoryExperimental interventionSchizophreniaNon-specific stimulationIntervention
2005
Differences in performance and learning proficiency on the Wisconsin Card Sorting Test in schizophrenia: Do they reflect distinct neurocognitive subtypes with distinct functional profiles?
Kurtz MM, Wexler BE. Differences in performance and learning proficiency on the Wisconsin Card Sorting Test in schizophrenia: Do they reflect distinct neurocognitive subtypes with distinct functional profiles? Schizophrenia Research 2005, 81: 167-171. PMID: 16243489, DOI: 10.1016/j.schres.2005.09.003.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAttentionCognition DisordersCuesDiscrimination LearningFemaleHumansLearning DisabilitiesMaleMemory, Short-TermMiddle AgedNeuropsychological TestsPractice, PsychologicalProblem SolvingPsychometricsPsychomotor PerformanceReaction TimeSchizophreniaSchizophrenic PsychologyConceptsWisconsin Card Sorting TestUCSD Performance-based Skills AssessmentCard Sorting TestSorting TestComprehensive neurocognitive test batteryPerformance-Based Skills AssessmentDifferent neurocognitive profilesNeurocognitive test batteryPerformance-based measuresBehavioral treatment interventionsSecond measureNeurocognitive subtypesNeurocognitive profileMotor sequencingWCST performancePoor learnersTest batteryGood learnersDistinct functional profilesSubtyping of patientsTreatment interventionsIndependent measuresLearnersSkills assessmentGreater functional capacityEffects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms
Sacco KA, Termine A, Seyal A, Dudas MM, Vessicchio JC, Krishnan-Sarin S, Jatlow PI, Wexler BE, George TP. Effects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms. JAMA Psychiatry 2005, 62: 649-659. PMID: 15939842, DOI: 10.1001/archpsyc.62.6.649.Peer-Reviewed Original ResearchConceptsVisuospatial working memoryWorking memoryAttentional deficitsCognitive deficitsOvernight abstinenceContinuous Performance Test scoresSpatial working memoryOutpatient mental health centersPerformance test scoresCognitive enhancementCPT performanceNeuropsychological assessmentSmoking reinstatementTobacco cravingControl smokersTest scoresCounterbalanced mannerMental health centersCognitive impairmentReinstatementSubjective effectsNicotine dependenceCigarette smokingDeficitsNicotinic receptor mechanisms