2014
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nature Communications 2014, 5: 4579. PMID: 25093396, PMCID: PMC4139707, DOI: 10.1038/ncomms5579.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionExecutive functionGeriatric depressionComputerized cognitive remediationTreatment-resistant geriatric depressionHistorical controlsBrain network abnormalitiesCognitive remediationPoor clinical outcomeGold standard treatmentRemission of symptomsOlder adultsClinical outcomesDepression treatmentMajor depressionDepressive symptomsNetwork abnormalitiesEscitalopramDepressionSymptomsGreater improvementTreatmentDeficitsRemissionParticipants
2004
Test–retest stability of neuropsychological testing and individual differences in variability in schizophrenia outpatients
Greig T, Nicholls SS, Wexler BE, Bell MD. Test–retest stability of neuropsychological testing and individual differences in variability in schizophrenia outpatients. Psychiatry Research 2004, 129: 241-247. PMID: 15661317, DOI: 10.1016/j.psychres.2004.09.006.Peer-Reviewed Original ResearchConceptsNeurocognitive functionImpact of treatmentTest-retest variabilityClinical trialsNeuropsychological testingStable outpatientsSchizoaffective disorderMeasures of psychopathologyTest-retest changesMost subjectsSchizophrenia outpatientsBaseline measuresNeuropsychological testsSchizophrenia researchTest-retest stabilityOutpatientsReliable instrumentSignificant changesTreatmentSubject variancePractice effectsSubjectsPatientsNeuropathology
1994
Neuroleptic exposure following inpatient treatment of acute mania with lithium and neuroleptic
Sernyak M, Griffin R, Johnson R, Pearsall H, Wexler B, Woods S. Neuroleptic exposure following inpatient treatment of acute mania with lithium and neuroleptic. American Journal Of Psychiatry 1994, 151: 133-135. PMID: 7903511, DOI: 10.1176/ajp.151.1.133.Peer-Reviewed Original Research
1992
The Outpatient Treatment of Depression
WEXLER B, CICCHETTI D. The Outpatient Treatment of Depression. The Journal Of Nervous And Mental Disease 1992, 180: 277-286. PMID: 1533868, DOI: 10.1097/00005053-199205000-00001.Peer-Reviewed Original ResearchConceptsTreatment failure rateTreatment success rateTreatment dropout ratesInitial treatmentRoutine treatmentOutpatient treatmentEffective treatmentDepressed outpatientsSide effectsClinical practiceCombined treatmentRoutine useIndividual psychotherapyMultiple studiesSuccess rateTreatmentPharmacotherapyModest advantageFailure rateDropout ratePsychotherapyUnnecessary costsPatientsOutpatients