2019
Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence
Kavanaugh BC, Cancilliere MK, Fryc A, Tirrell E, Oliveira J, Oberman LM, Wexler BE, Carpenter LL, Spirito A. Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence. Child Neuropsychology 2019, 26: 754-769. PMID: 31876232, PMCID: PMC10629577, DOI: 10.1080/09297049.2019.1708295.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomatologyGlobal deficit scoreDepressive symptomatologyDetection of impairmentHealth ToolboxDepressive symptom varianceNational InstituteChildhood/adolescenceSelf-reported depressionComparable psychometric propertiesSymptom varianceEF symptomsDeficit scoresDepression diagnosisDepressive symptomsClinical diagnosisChild-reported anxietyClinical neuropsychological measuresImpairmentMeasures of EFSymptomatologyDepressionNeuropsychological measuresSymptomsParent report
2014
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nature Communications 2014, 5: 4579. PMID: 25093396, PMCID: PMC4139707, DOI: 10.1038/ncomms5579.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionExecutive functionGeriatric depressionComputerized cognitive remediationTreatment-resistant geriatric depressionHistorical controlsBrain network abnormalitiesCognitive remediationPoor clinical outcomeGold standard treatmentRemission of symptomsOlder adultsClinical outcomesDepression treatmentMajor depressionDepressive symptomsNetwork abnormalitiesEscitalopramDepressionSymptomsGreater improvementTreatmentDeficitsRemissionParticipants
2004
Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia
Dolan SL, Sacco KA, Termine A, Seyal AA, Dudas MM, Vessicchio JC, Wexler BE, George TP. Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia. Schizophrenia Research 2004, 70: 263-275. PMID: 15329302, DOI: 10.1016/j.schres.2004.01.006.Peer-Reviewed Original ResearchConceptsNon-psychiatric control smokersTreatment failureStroop Color-Word TestContinuous Performance TestNeuropsychological deficitsControl smokersWisconsin Card Sorting TestPlacebo-controlled trialAtypical antipsychotic treatmentCessation treatmentAntipsychotic treatmentCessation interventionsCigarette smokingDepressive symptomsPharmacological agentsColor-Word TestSmokingNeuropsychological assessmentNeuropsychological performanceCard Sorting TestVisuospatial Working Memory TaskGreater deficitsPreliminary dataSmokersPatients
2001
Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia
George TP, Vessicchio JC, Termine A, Sahady DM, Head CA, Pepper WT, Kosten TR, Wexler BE. Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia. Neuropsychopharmacology 2001, 26: 75-85. PMID: 11751034, DOI: 10.1016/s0893-133x(01)00296-2.Peer-Reviewed Original ResearchConceptsVisuospatial working memorySmoking abstinenceStroop Color-Word TestAbstinence-induced changesWorking Memory FunctionColor-Word TestPlacebo-controlled smoking cessation trialFunction of genderWorking memoryCigarette smokingWord TestSmoking cessation trialCognitive functionCognitive deficitsMemory functionNicotine-dependent cigarette smokersNon-smoking controlsSignificant impairmentPathophysiology of schizophreniaDopamine functionCortical dopamine functionCessation trialSchizophrenic smokersDepressive symptomsAbstinence