2020
An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder
Wexler BE, Vitulano LA, Moore C, Katsovich L, Smith SD, Rush C, Grantz H, Dong J, Leckman JF. An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder. Psychological Medicine 2020, 51: 1524-1535. PMID: 32090720, DOI: 10.1017/s0033291720000288.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderExperimental medicine approachTAU groupMedicine approachHyperactivity disorderWeeks of treatmentCombined subtypeDiagnosis of ADHDClinical trial designHyperactive-impulsive subtypeAttention-deficit/hyperactivity disorderCross-over designDeficit hyperactivity disorderClinical improvementClinical symptomsRandomized crossCognitive dysfunctionCT groupPathophysiological heterogeneityCONSORT recommendationsTrial designResponse rateChange scoresSubtypesTargeted pathology
2001
Neurocognitive Enhancement Therapy With Work Therapy: Effects on Neuropsychological Test Performance
Bell M, Bryson G, Greig T, Corcoran C, Wexler BE. Neurocognitive Enhancement Therapy With Work Therapy: Effects on Neuropsychological Test Performance. JAMA Psychiatry 2001, 58: 763-768. PMID: 11483142, DOI: 10.1001/archpsyc.58.8.763.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCognitionCognition DisordersComputer-Assisted InstructionDichotic Listening TestsFeedbackFemaleFrontal LobeHumansMaleMemoryMultivariate AnalysisNeuropsychological TestsOccupational TherapyPsychomotor PerformancePsychotic DisordersSchizophreniaSchizophrenic PsychologyTeachingTreatment OutcomeConceptsNeurocognitive enhancement therapyEnhancement therapyWork therapyMental activityNeuropsychological testingLarge effect size improvementsExecutive function tasksNeuropsychological test performanceEffect size improvementsComputer-based trainingFunction tasksExecutive functionMemory performanceCognitive performanceNeuropsychological testsTraining tasksCognitive deficitsTest performanceComputer trainingCognitive dysfunctionIndependent outcome measureOccupational dysfunctionNatural contextSchizoaffective disorderMemory
1998
Cortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging
Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler BE. Cortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging. JAMA Psychiatry 1998, 55: 1097-1103. PMID: 9862553, DOI: 10.1001/archpsyc.55.12.1097.Peer-Reviewed Original ResearchConceptsSerial position taskFunctional magnetic resonance imagingInferior frontal gyrusPosition taskMemory deficitsFrontal gyrusLeft inferior frontal gyrusAnterior temporal lobe areasTask-specific activationFunctional magnetic resonanceSpeech-related areasCortical hemodynamic responsesTemporal lobe areasSevere cognitive deficitsAuditory wordsWorking memoryVerbal learningNeural basisSuch deficitsCognitive deficitsCognitive functionParietal lobeLobe areasMagnetic resonance imagingCognitive dysfunction