Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study
Sinha R, Lacadie C, Skudlarski P, Fulbright RK, Rounsaville BJ, Kosten TR, Wexler BE. Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study. Psychopharmacology 2005, 183: 171-180. PMID: 16163517, DOI: 10.1007/s00213-005-0147-8.Peer-Reviewed Original ResearchConceptsStress-induced cocaineCocaine-dependent individualsFunctional magnetic resonance imaging sessionNeural activityFunctional magnetic resonance imaging studyMagnetic resonance imaging sessionCocaine cravingRegulation of emotionHippocampal/parahippocampal regionLevel-dependent signal changesRight fusiform gyrusStress-related vulnerabilityPara-limbic regionsAnterior cingulate regionsRight postcentral gyrusDependent signal changesMagnetic resonance imaging studyResonance imaging studyStress processingFusiform gyrusNeutral situationsSpecific frontalBOLD activationPersonal stressCingulate regionsCue-Induced Brain Activity Changes and Relapse in Cocaine-Dependent Patients
Kosten TR, Scanley BE, Tucker KA, Oliveto A, Prince C, Sinha R, Potenza MN, Skudlarski P, Wexler BE. Cue-Induced Brain Activity Changes and Relapse in Cocaine-Dependent Patients. Neuropsychopharmacology 2005, 31: 644-650. PMID: 16123763, DOI: 10.1038/sj.npp.1300851.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingPosterior cingulate cortexCocaine-related cuesCocaine-dependent patientsBrain activationTreatment effectiveness scoreSensory association corticesBrain activity changesPCC activationCocaine cuesSuperior temporalBOLD activationCingulate cortexSubjective reportsTreatment developmentAssociation cortexCuesProcessing areasCocaine abusePhysiological activationCortexNonrelapsersBest predictorCocaine-free urinesDrug use